在不利的环境条件下保护撕裂膜的稳定性,使用带有非牛顿粘度剂的粘膜仿真剂
Ali Abusharha1, E Ian Pearce2, Tayyaba Afsar3
1Department of Optometry, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.
Medicina (Kaunas, Lithuania)
|October 28, 2023
概括
茄子种子多糖化物 (TSP) 和氨酸 (HA) 眼滴在干燥环境中显著保护眼膜参数. 保护和缓解方法都在改善脂质层厚度和撕裂稳定性方面被证明是有效的.
科学领域:
- 眼科医生 眼科 眼科
- 药物运输 药物运输 药物运输
- 生物材料是一种生物材料.
背景情况:
- 茄子种子的多糖化物 (TSP) 和氨酸 (HA) 具有有利于眼部药物递送的粘膜粘合性.
- 这些特性可以增强药物吸收,并延长眼睛表面的停留时间,可能缓解干眼症状.
研究的目的:
- 评估一种含有TSP/HA的配方在治疗因恶劣环境条件引起的干眼症状时的有效性.
- 在干燥应力下,研究粘合模拟聚合物和撕裂膜关键参数之间的相互作用.
主要方法:
- 参与者暴露在受控的低湿度环境中 (5%RH).
- 评估了眼膜的参数,包括非侵入性眼破裂时间 (NITBUT),眼蒸发率和脂质层厚度 (LLT).
- 用TSP/HA眼滴进行了两种方式:保护 (暴露前) 和缓解 (暴露后).
主要成果:
- 与40%的RH相比,暴露于5%的RH显著降低了LLT,增加了眼蒸发率.
- 在5%的RH下,TSP/HA眼滴在保护和缓解治疗组中显著增强了LLT和改善了NITBUT.
- 该配方在保护模式中显示出对增加蒸发的保护作用.
结论:
- 在干燥的环境中,TSP/HA眼液可显著保护膜参数.
- 暴露前 (保护) 和暴露后 (缓解) 的两种施用方法都是有效的.
- 包括TSP/HA增强了眼滴对不利环境条件的保护能力.
相关概念视频
Viscosity of Fluid
434
Viscosity measures the resistance a fluid offers to flow and deformation. It results from internal friction between layers of fluid moving relative to one another. Dynamic viscosity, denoted by the Greek letter mu (μ), quantifies the force needed to move one fluid layer over another. For Newtonian fluids like water and air, the relationship between the shearing stress and the rate of shearing strain is linear, meaning their viscosity remains constant regardless of the applied stress.
434
Membrane Fluidity
152.7K
Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
152.7K
Surface Tension, Capillary Action, and Viscosity
27.9K
Surface Tension
The various IMFs between identical molecules of a substance are examples of cohesive forces. The molecules within a liquid are surrounded by other molecules and are attracted equally in all directions by the cohesive forces within the liquid. However, the molecules on the surface of a liquid are attracted only by about one-half as many molecules. Because of the unbalanced molecular attractions on the surface molecules, liquids contract to form a shape that minimizes the number...
The various IMFs between identical molecules of a substance are examples of cohesive forces. The molecules within a liquid are surrounded by other molecules and are attracted equally in all directions by the cohesive forces within the liquid. However, the molecules on the surface of a liquid are attracted only by about one-half as many molecules. Because of the unbalanced molecular attractions on the surface molecules, liquids contract to form a shape that minimizes the number...
27.9K
Types of Fluids
287
Fluids can be classified into Newtonian and non-Newtonian fluids based on their response to shear stress. Newtonian fluids have a linear relationship between shear stress and the shear strain rate, following Newton's law of viscosity. Their viscosity remains constant regardless of the shear rate, making their behavior predictable and easier to analyze. Common examples include water, air, oil, and gasoline.
In contrast, non-Newtonian fluids do not follow Newton's law of viscosity, and...
In contrast, non-Newtonian fluids do not follow Newton's law of viscosity, and...
287
Newtonian Fluid: Problem Solving
234
Newtonian fluids exhibit a constant viscosity, meaning their shear stress and shear strain rate are directly proportional. This property ensures a predictable and stable response to applied forces, maintaining a linear relationship between force and flow. Examples include water, air, and light oils, consistently demonstrating this proportional behavior regardless of external conditions.
A velocity gradient forms within the fluid when a Newtonian fluid is placed between two parallel plates, with...
A velocity gradient forms within the fluid when a Newtonian fluid is placed between two parallel plates, with...
234


