相关实验视频

Updated: Jul 12, 2025

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

Published on: April 22, 2022

聚醇-聚糖合物复合物的抗氧化和抗衰老特性从Hizikia fusiforme中提取出来

Shangkun Li^1,2,3,4, Yunhai He^1,3,4, Saiyi Zhong²

¹College of Food Science and Engineering, Dalian Ocean University, Dalian 116000, China.

Foods (Basel, Switzerland)

|October 28, 2023

概括

希兹基亚状多-多糖复合物显示出强大的抗衰老作用. 这些化合物调节抗氧化途径和肠道微生物群,表明它们作为天然抗衰老药物的潜力.

科学领域:

海洋天然产品海洋天然产品
生物化学生物化学
老年学是指老年学的学科.

背景情况:

传统上,Hizikia fusiforme被用于医疗目的.
来自植物的多多糖化合物 (PPC) 具有增强的生物活性.
研究来自H. fusiforme的PPC及其健康益处.

研究的目的:

从Hizikia fusiforme中分离和表征多多糖化合物 (PPC) 复合物.
评估这些PPC的体外抗氧化和体内抗衰老活性.
探索抗衰老作用的潜在机制,包括Nrf2通路调节和肠道微生物群变化.

主要方法:

酶性水解和微分酒精沉被用于获得PPC.
进行了体外抗氧化剂测试,以选活性化合物.
在体内抗衰老研究中使用了D-银糖诱导的老化小鼠模型.
进行了基因和蛋白质表达分析 (Nrf2通路),以及肠道微生物群分析.

主要成果:

两种PPC (PPC1,PPC2) 被分离出来,其中PPC2显示出更高的抗氧化活性.
产生了脱化PPCs (PPC3,PPC4),而PPC4也表现出显著的抗氧化能力.
在体内研究表明,PPCs调节了抗氧化酶,对大脑中的Nrf2通路进行了上调,并改善了肠道微生物群组成 (增加了Bacteroidota/Firmicute比率).

结论:

由Hizikia fusiforme衍生的多-多糖化合物具有显著的抗氧化和抗衰老特性.
PPCs调节关键分子通路 (Nrf2) 和肠道微生物群,有助于它们的抗衰老作用.
H. fusiforme PPC 显示出作为与年龄有关的疾病的天然治疗剂的潜力.

关键词:

一个状的 Hizikia.抗衰老的抗衰老的抗氧化作用抗氧化作用我们的肠道微生物群.聚烯多糖化合物复合物

更多相关视频

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Published on: July 5, 2017

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

Published on: June 2, 2023

相关概念视频

Cellulose and Pectic Polysaccharides

Cellulose and Pectic Polysaccharides

Every plant cell has a cell wall that protects the cell, provides structural support, and gives the cell shape. Cellulose, the main structural component of the plant cell wall, makes up over 30% of plant matter. It is the most abundant organic compound on earth. Cellulose is an unbranched polysaccharide composed of linear chains of glucose molecules linked by β (1→4) glycosidic bonds.
As a cell matures, its cell wall specializes according to its type. For example, the...

Oxidation of Phenols to Quinones

Oxidation of Phenols to Quinones

In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...