来自Laminaria japonica的低分子量多糖的潜在低血糖能力
Aijun Tong1,2, Dengwei Wang3, Xiaoyan Liu4
1College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Foods (Basel, Switzerland)
|October 28, 2023
概括
来自Laminaria japonica (LJOO) 的低分子量多糖有效降低了2型糖尿病小鼠模型中的血糖. 此外,LJOO还改善了肠道微生物群平衡,并增加了有益的短链脂肪酸 (SCFA).
科学领域:
- 营养科学 营养科学
- 微生物学 微生物学
- 生物化学 生物化学
背景情况:
- 2型糖尿病 (T2DM) 是一种代谢障碍,通常与肠道微生物群失调有关.
- 饮食干预措施,包括使用海洋衍生化合物的干预措施,正在探索T2DM管理.
研究的目的:
- 评估来自Laminaria japonica (LJOO) 的低分子量多糖的低血糖作用.
- 在T2DM小鼠模型中研究LJOO对肠道微生物群组成和短链脂肪酸 (SCFA) 生产的影响.
主要方法:
- 建立了一个T2DM小鼠模型,并通过连续测量4周用LJOO进行治疗.
- 测量了生物化学参数,包括禁食血糖 (FBG) 和胰岛素.
- 用16S rDNA测序分析了肠道微生物组的组成,并量化了肠道SCFA.
主要成果:
- 在T2DM小鼠中,LJOO显著降低了FBG和胰岛素度.
- 施用LJOO调节了肠道微生物群,增加了有益的细菌 (例如益生菌) 和 Bacteroidetes/Firmicutes 的比例,同时减少了有害的细菌.
- LJOO促进了产生SCFA的细菌,导致内SCFA水平升高.
结论:
- LJOO证明了低血糖疗效和对T2DM的潜在治疗益处.
- 通过改善肠道微生物群失调和增强SCFA生产,LJOO可以缓解T2DM.
- 作为T2DM患者的功能性食补充剂,LJOO显得有前途.
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