患有慢性肝胆道疾病的狗的肠道微生物群:我们可以谈谈肠肝轴吗?
Verena Habermaass1, Daniela Olivero2, Eleonora Gori1
1Department of Veterinary Sciences, University of Pisa, Via Livornese Lato Monte, 56122 Pisa, Italy.
Animals : an open access journal from MDPI
|October 28, 2023
概括
肠道微生物组在患有慢性肝胆道疾病的狗中发生变化,特别是胆固醇病. 这种肠道失调突显了肠肝轴在狗健康中的重要性.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 肠肝轴是人类医学研究的一个重要领域,肠道微生物组 (GM) 变化和慢性肝胆道疾病 (CHD) 之间已建立联系.
- 然而,这些相互作用在兽医学中仍然基本上未被探索,特别是在狗身上.
研究的目的:
- 调查和描述诊断为慢性肝胆道疾病 (CHD) 的狗的肠道微生物组变化.
- 根据临床和生化变量,比较转基因资料,包括胆固醇,内分泌疾病和饮食.
主要方法:
- 预计将招收65只狗,进行临床和血液生化评估.
- 使用16S-RNA基因测序来评估肠道微生物组合.
- 接受抗生素或pre/pro/symbiotics的狗被排除在外,以确保准确的转基因分析.
主要成果:
- 与没有的狗相比,在胆固醇性心血管疾病的狗中观察到显著的转基因变化.
- 胆固醇病与特定细菌种群的减少有关 (例如, *Clostridium hiranonis *, *Fusobacterium *, *Megamonas *, *Ruminococcus faecis *, *Turicibacter *).
- 患有胆固醇病的狗显示出 *Escherichia/Shigella *和 *Serratia * 的水平增加.
结论:
- 胆汁流和胆汁成分在胆固醇状态下发生的变化直接影响肠道微生物环境,导致肠道失调.
- 临床医生应考虑肠 - 肝相互作用和潜在的功能失调在管理CHD的狗,特别是胆固醇的形式.
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