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狗的纤维细胞生长因子-23 (FGF-23) - 参考间隔和与血液学和生物化学参数的相关性

Sandra Lapsina¹, Nicole Nagler¹, Simon Franz Müller¹

¹LABOKLIN GmbH and Co. KG, Steubenstraße 4, 97688 Bad Kissingen, Germany.

Animals : an open access journal from MDPI

|October 28, 2023

概括

纤维细胞生长因子-23 (FGF-23) 的测定在狗中显示出很好的精度. 建立了一个广泛的参考间隔,FGF-23水平因年龄和功能而异,这表明需要对犬类慢性病进行个性化监测.

科学领域:

兽医医学兽医医学兽医医学
内分泌学在内分泌学.
生物化学生物化学

背景情况:

纤维细胞生长因子-23 (FGF-23) 是一种关键的素激素,与监测人类慢性病 (CKD) 有关.
建立可靠的FGF-23测量方法和参考间隔对于犬类临床诊断至关重要.

研究的目的:

通过使用Kainos ELISA套件,确定犬体FGF-23度的内部和间测试精度.
在临床上健康的狗中计算FGF-23的参考间隔.
评估FGF-23度与血液学/生物化学参数,特别是脏标志物之间的相关性.

主要方法:

凯诺斯ELISA FGF-23套件的测试内和测试间精度分析.
在136只临床健康的狗中确定FGF-23参考间隔.
根据IRIS肌素分类和年龄分阶段的狗FGF-23水平的回顾性分析.

主要成果:

FGF-23试验显示出良好的可重复性,变化系数低于15%.
在健康狗中,FGF-23的参考间隔被确定为95.8695.1 pg/mL.
在不同年龄组 (<9 vs. ≥9年) 和在IRIS CKD阶段之间观察到FGF-23水平的显著差异,与参数的相关性最强.

结论:

凯诺斯ELISA套件为狗提供精确的FGF-23测量.
已建立的参考间隔和观察到的变化突显出需要进一步研究FGF-23在狗脏疾病中的作用.
由于基准范围很广,诊断截止值或特定主体的参考值可能是必要的,以有效监测狗狗FGF-23的临床监测.

关键词:

在FGF-23中.狗类犬类动物狗类犬类慢性脏疾病慢性脏疾病临床病理学临床病理学脏脏的脏

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