状树叶和相邻的第一个永久的微生物关系
Weihua Shi1,2, Jing Tian1, He Xu1
1Department of Pediatric Dentistry, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials, Beijing 100081, China.
Microorganisms
|October 28, 2023
概括
根据微生物群对叶落性虫的分类可以预测永久性虫的未来空洞. 这种微生物分析有助于识别患有牙进展风险较高的儿童.
科学领域:
- 口腔微生物学 口腔微生物学
- 儿科牙科 儿科牙科
- 牙虫研究 牙虫研究
背景情况:
- 枯叶性虫病往往比永久性虫病更严重.
- 了解落叶虫和永久性虫之间的联系对于早期干预至关重要.
研究的目的:
- 为了研究落叶性虫的亚型和第一个永久的虫之间的关联.
- 探索不同虫群体中口腔微生物群的分类学和功能概况.
主要方法:
- 招募了42名混合牙的儿童,分为无牙,仅牙,牙和永久牙组.
- 在树叶和永久牙的上牙斑上进行了元基因组测序.
- 分析了微生物群的基于物种的β多样性,组成和功能概况.
主要成果:
- 在多叶 (DMC) 和多叶和永久 (C) 群体之间观察到微生物群组成和功能的显著差异.
- 在C组中确定了14种与虫相关的物种和途径,可能会将叶片虫与永久性虫联系起来.
- 在DMC组中,特定的细菌 (例如, *Leptotrichia wadei*, *Streptococcus anginosus*) 和永久牙中的代谢途径反映了C组的情况,表明脏风险升高.
结论:
- 以微生物群为基础的叶虫的分类可以预测相邻的第一永久虫的虫风险.
- 即使在临床上是健康的,也可以通过微生物分析来早期识别有风险的永久性牙.
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