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婴儿近肠残留肠道微生物群概况的变化,这些婴儿接受了需要静脉切口术的手术
Inês Barreiros-Mota1,2, João R Araújo1,3, Cláudia Marques1,3
1Nutrition & Metabolism Department, NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), Universidade NOVA de Lisboa, 1169-056 Lisbon, Portugal.
Microorganisms
|October 28, 2023
概括
接受肠道手术的婴儿在三周内表现出积极的肠道微生物群转移. 关键的变化包括总细菌和有益的乳酸菌的增加,而斯塔菲洛科克和坎迪达菌的减少,这表明手术后肠道健康得到改善.
科学领域:
- 微生物学 微生物学
- 儿科手术 儿科手术
- 胃肠病学 胃肠病学
背景情况:
- 早期的肠道失调与后来的炎症性,代谢性和免疫性疾病有关.
- 有限的数据存在于肠道外科手术后肠静脉切割的婴儿肠道微生物群的变化.
研究的目的:
- 为了研究肠道微生物群的变化,在肠道手术后的婴儿需要肠道.
- 分析手术对细菌和真菌种群和多样性的影响.
主要方法:
- 对29名接受肠道手术的婴儿进行前性队列研究.
- 在两个时间点 (手术后立即和3周后) 使用实时PCR和16SrRNA基因测序分析肠道排泄物微生物群.
主要成果:
- 三周后,总细菌 (+21%) 和乳酸菌 (+3%) 显著增加.
- 在葡萄球菌 (-21%) 和Candida spp.显著下降. (-16%). 这是一个很大的变化.
- 观察到α多样性的增加和β多样性的改变;死性肠球炎与较高的葡萄球菌和α多样性相关.
结论:
- 接受肠道手术的婴儿在手术后三周内表现出肠道微生物群的积极变化.
- 这些变化表明,肠道微生物群体在这个脆弱群体中的潜在恢复或适应.
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