连续便微生物群输液通过结肠镜治疗活性性结肠炎:意大利的一项可行性,安全性和转化单心研究
Loris Riccardo Lopetuso1,2,3, Lucrezia Laterza1, Valentina Petito1,4
1IBD Unit, CEMAD, Digestive Diseases Center, Medicina Interna e Gastroenterologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, L. Go A. Gemelli 8, 00168 Rome, Italy.
通过结肠镜进行连续便微生物群移植 (FMT) 显示出治疗性结肠炎 (UC) 的前景. 这种安全可行的方法可以诱导和维持临床反应,特定的肠道细菌预测治疗成功.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病,治疗选择有限.
- 便微生物群移植 (FMT) 对UC的疗效尚未完全确定.
- 了解肠道微生物群在UC病变发生中的作用至关重要.
研究的目的:
- 评估在活跃的UC患者中连续输注FMT的可行性和有效性.
- 为了将FMT结果与接受Infliximab的对照组进行比较.
- 为了确定治疗反应的微生物预测因素.
主要方法:
- 19名患有轻度至中度活性UC的患者通过结肠镜连续三次接受FMT输液.
- 一个对照组接受了Infliximab治疗.
- 评估了临床,内镜和微生物结局,以及不良事件.
主要成果:
- 临床反应在第12周观察到9/19名患者,并在第8/19周维持在24周.
- 到第12周,在6/19名患者中实现了内镜缓解.
- 与非响应者相比,响应者显示出更高的微生物群丰富度和特定细菌丰富度 (例如,Faecalibacterium,Akkermansia).
结论:
- 连续的FMT输液是可行的,安全的,有效的诱导和维持UC的临床反应.
- 特定的肠道细菌简介可以预测UC患者的FMT反应.
- FMT代表了性结肠炎的潜在治疗策略.
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