微生物群的异常发育可能是婴儿发烧性尿路感染的危险因素
Chika Urakami1,2, Sohsaku Yamanouchi1, Takahisa Kimata1
1Department of Pediatrics, Kansai Medical University, Osaka 573-1010, Japan.
Microorganisms
|October 28, 2023
概括
婴儿发烧性尿路感染 (fUTIs) 与肠道微生物群的异常发育有关. 下肠道微生物多样性和患有fUTI的婴儿增加的Escherichia-Shigella表明潜在的危险因素.
科学领域:
- 微生物学 微生物学
- 儿科 儿科 儿科
- 胃肠病学 胃肠病学
背景情况:
- 发烧性尿路感染 (fUTIs) 在婴儿中很常见,但风险因素仍然不清楚.
- 肠道细菌上升到泌尿道往往导致FUTI,这表明肠道失调可能起作用.
- 婴儿肠道微生物群发育与fUTI风险之间的关系需要进一步研究.
研究的目的:
- 测试假设,婴儿时期肠道微生物群的异常发育增加了fUTI的风险.
- 为了比较fUTI和没有fUTI的婴儿之间的肠道微生物多样性和组成.
主要方法:
- 便样本从3至11个月龄的婴儿和年龄相匹配的健康对照中收集.
- 提取了细菌DNA,并进行了16S rRNA基因测序,以分析肠道微生物群.
- 阿尔法和β多样性,以及特定的细菌种群,在fUTI和健康对照组之间进行了比较.
主要成果:
- 与健康对照组相比,患有fUTI的婴儿表现出明显较低的肠道微生物α多样性 (Shannon和Chao指数) (p < 0.001).
- 贝塔多样性分析显示,fUTI和健康对照组之间存在明显的聚类 (p < 0.001),表明微生物组成的差异.
- 与健康对照组 (3.1%;p < 0.001) 相比,fUTI组在肠道微生物群中显示出埃舍里希亚-希格拉菌的比例明显更高 (9.5%).
结论:
- 肠道微生物群的异常发展,其特点是减少多样性和增加埃舍里希亚-西格拉菌,可能是婴儿fUTI的重要危险因素.
- 这些发现强调了肠道微生物在婴儿尿路感染中的潜在作用.
- 对调节婴儿肠道微生物群的进一步研究可能为预防FUTI提供新的策略.
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