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尼尔马特雷尔维尔/里托纳维尔是否会影响针对SARS-CoV-2的免疫反应,而不是反弹?

Francesca Panza^1,2, Fabio Fiorino^3,4, Gabiria Pastore³

¹Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.

|October 28, 2023

概括

尼尔马特里尔维尔/里托纳维尔治疗后COVID-19症状的复发可能与免疫反应减弱有关. 与未接受抗病毒治疗的患者相比,接受抗病毒治疗的患者显示出较低的抗高峰IgG和改变的细胞因子概况.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
药理学药理学是指药理学的学科.

背景情况:

在尼尔马特里尔维尔/里托纳维尔治疗后,已经观察到COVID-19症状的复发和病毒载荷的复发.
驱动这种现象的潜在免疫机制仍然不清楚.

研究的目的:

在接受尼马特里尔维尔/里托纳维尔治疗的患者中,研究宿主免疫反应和病毒反弹之间的关系.
将经历COVID-19反弹的患者的免疫特征与对照组进行比较.

主要方法:

在nirmatrelvir/ritonavir治疗后 (A组) 描述了三起COVID-19复发病例.
在复发病例 (A组),非复发治疗病例 (B组) 和未经治疗的对照 (C组) 之间比较了尖端特异性抗体反应和血细胞因子/化学因子模式.

主要成果:

抗抗体和细胞因子模式在涅马特雷尔维尔/里托纳维尔治疗组 (A和B) 之间是相似的.
与治疗组 (A和B) 相比,没有抗病毒治疗的患者 (C组) 呈现出明显更高的抗BA.2尖峰IgG反应.
与C组相比,接受抗病毒治疗的患者 (A-B组) 显示PDGF-BB和VEGF升高,IL-9,IL-1 RA和RANTES降低.

结论:

与未接受治疗的患者相比,接受涅马特里尔维尔/里托纳维尔治疗的患者表现出较低的抗峰IgG水平和明显的细胞因子概况.
早期的抗病毒治疗可能通过减少病毒载量和抗原呈现来减轻SARS-CoV-2的免疫反应.
需要在更大的队列中进行进一步的研究,以确定这些发现的临床意义.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.免疫反应的免疫反应.尼尔马特雷尔维尔 / 里托纳维尔在反弹的过程中,反弹是反弹.

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