微生物群对泌尿器官恶性瘤的影响:系统性审查
Joao G Porto1, Maria Camila Suarez Arbelaez1, Brandon Pena1,2
1Desai Sethi Urology Institute, University of Miami, Miller School of Medicine, Miami, FL 33136, USA.
Cancers
|October 28, 2023
概括
泌尿器官微生物组显著影响癌症的发展. 这篇评论强调了它在前列腺,膀和癌中的作用,并提出了新的治疗和生物标志物机会.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 微生物组在癌症中的作用越来越被认可,但尿道癌症中的泌尿器官微生物研究不足.
- 研究主要集中在肠道微生物群上,在了解泌尿生殖器微生物影响方面存在差距.
研究的目的:
- 系统地审查有关泌尿器官微生物在各种尿道恶性瘤中的作用的文献.
- 为了确定与前列腺,膀,脏,阴茎和丸癌的特定微生物关联.
- 探索与泌尿器官微生物组相关的潜在治疗策略和生物标志物发现.
主要方法:
- 科学文献的系统审查.
- 分析了37项专注于泌尿癌及其相关微生物组的研究.
- 根据癌症类型对研究进行分类:前列腺癌 (12),膀癌 (20),脏癌 (4),阴茎癌/丸癌 (1).
主要成果:
- 对于不同类型的泌尿癌,确定了明显的微生物关联.
- 该审查综合了前列腺,膀,脏和阴茎/丸癌症研究的发现.
- 有证据表明,泌尿器官微生物组与癌症进展有关.
结论:
- 泌尿器官微生物组在泌尿癌的发展和进展中起着复杂的作用.
- 进一步的研究至关重要,以充分阐明这些微生物的作用,并将发现转化为临床应用.
- 在泌尿器官微生物群中存在新的治疗标和诊断生物标记物的潜力.
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