在小肠腺癌中循环D1表达的预后意义
Sun-Young Jun1, Seung-Mo Hong2, Kee-Taek Jang3
1Department of Pathology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 21431, Republic of Korea.
Cancers
|October 28, 2023
概括
高循环D1表达在小肠腺癌 (SIAC) 中很常见,表明更好的预后. 这一发现可能会为这种罕见的癌症的未来治疗提供信息.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- 环素D1是细胞循环进展的关键调节剂,也是潜在的治疗标.
- 由于瘤罕见,小肠腺癌 (SIAC) 中的环素D1表达尚不清楚.
研究的目的:
- 调查SIACs中cyclin D1表达的临床病理和预后意义.
- 为了确定环素D1的表达是否可以作为SIAC患者的预后生物标志物.
主要方法:
- 一项多机构研究分析了232个手术切除的初级SIACs.
- 评估了环素D1表达水平,并与临床病理特征和患者存活率相关联.
- 多变量分析确定了独立的预后指标.
主要成果:
- 在63%的SIAC中观察到高循环D1表达 (循环D1高),明显高于正常的粘膜 (11%).
- 循环D1高与较低的T类,较低的疾病阶段,KRAS突变和更好的患者存活率有关.
- 多变量分析证实了环林D1高作为一个独立的有利预后指标,特别是在早期的SIACs.
结论:
- 赛克林D1在SIACs中经常过度表达.
- 高循环D1表达是SIAC患者的有利预后指标.
- 这些发现有助于理解环素D1在SIAC致癌和治疗策略中的作用.
相关概念视频
02:34Inhibition of Cdk Activity
4.8K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.8K
02:39Positive Regulator Molecules
5.5K
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
5.5K
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.1K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K
01:23Renewal of Intestinal Stem Cells
2.6K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.6K
02:07Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K