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在HR+HER2-乳腺癌中的YAP1表达:21基因复发率得分分析和公共数据集验证

Inho Park^1,2, Yangkyu Lee^1,3, Jee Hung Kim^3,4

¹Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Republic of Korea.

|October 28, 2023

概括

YAP1表达与激素受体阳性,HER2阴性乳腺癌的风险得分较低有关. 较高的YAP1水平表明更好的结果,表明YAP1作为预后标志物.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

YAP1是一种瘤基因,也是Hippo路径的下游效应因子.
它在各种癌症中发挥作用.
这项研究研究了YAP1在激素受体阳性,HER2-阴性 (HR+HER2-) 乳腺癌中.

研究的目的:

检查YAP1表达与瘤型Dx (ODX) 测试风险评分 (RS) 在HR+HER2-乳腺癌中的关系.
使用公共数据集验证YAP1的预后值.

主要方法:

对401名经过ODX测试的HR+HER2-乳腺癌患者进行了回顾性分析.
通过免疫组织化学评估YAP1核定位.
与临床病理学参数和ODX RS. 的相关性分析.
使用TCGA-BRCA和METABRIC公共数据集进行验证.

主要成果:

YAP1表达与ODX RS (OR 0.373,p=0.002) 有负相关性.
升高的YAP1mRNA水平与改善的临床结果相关,特别是在ER阳性患者中.
在验证数据集 (METABRIC,TCGA-BRCA) 中观察到显著的生存益处 (OS,RFS,DFS).

结论:

在HR+HER2-乳腺癌中,YAP1表达与ODX风险评分相反相关.
YAP1可以作为一个有价值的预后生物标志物.
对于这个患者群体来说,YAP1是一个潜在的治疗标.

关键词:

是的相关蛋白1 是的相关蛋白1 乳腺新生体的发生.雌激素雌激素雌激素是一种病理学的病理学预后预后预后这些受体是受体受体.

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