在局部晚期宫癌中解读系统性炎症预测因子的复杂性,使用血红蛋白作为隐藏的关键 (ESTHER研究)
Federica Medici1,2, Martina Ferioli1, Ludovica Forlani1,2
1Radiation Oncology, Department of Medical and Surgical Sciences-DIMEC, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.
Cancers
|October 28, 2023
概括
系统性炎症指数 (IIs) 不能预测局部晚期宫癌 (LACC) 患者用化学辐射 (CRT) 治疗的结果. 年龄和血红蛋白水平等临床因素是整体存活率的更重要的预测因素.
科学领域:
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
- 临床研究 临床研究
背景情况:
- 局部晚期宫癌 (LACC) 治疗依赖于并发化疗 (CRT).
- 预测模型对于个性化LACC治疗和改善患者治疗结果至关重要.
- 在LACC中系统性炎症指数 (IIs) 的预后意义仍然不清楚.
研究的目的:
- 评估治疗前系统性炎症指数 (IIs) 与LACC患者的生存结果之间的关联.
- 为了比较IIs的预测值与LACC预后中确定的临床因素.
主要方法:
- 对173名LACC患者的预治疗数据进行了回顾性分析.
- 评估多种炎症指数 (例如NLR,PLR,APRI) 和临床变量.
- 对于局部控制 (LC),远程无转移生存率 (DMFS),无疾病生存率 (DFS) 和整体生存率 (OS) 的单变量和多变量考克斯回归分析.
主要成果:
- 单变量分析表明年龄,HB水平,瘤阶段,FIGO阶段和CRT剂量与生存结果之间的相关性.
- 一些II (NLR,PLR,APRI,ANRI,COP-NLR) 仅与当地控制表现出单变量关联.
- 多变量分析确定Hb水平,CRT剂量和年龄是OS的显著预测因素;没有II是显著预测因素.
结论:
- 在接受CRT的LACC患者中,治疗前系统性炎症指数似乎不是对生存结果的显著预测指标.
- 临床因素,如血红蛋白水平,CRT剂量和年龄,是这个队列中整体存活率的更强有力的预测因素.
- 这些发现表明需要进一步研究混变量和IIs在LACC预后中的作用.
相关概念视频
Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Role of Hematopoietic Growth Factors
1.4K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Thrombopoietin (TPO), mainly released by the liver,...
1.4K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
99
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
99


