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古塔珀查改善了含有聚二甲基氧基根管道密封剂的生物玻璃的体外生物活性和牙重矿化能力

Paola Taddei¹, Michele Di Foggia¹, Fausto Zamparini²

¹Biochemistry Unit, Department of Biomedical and Neuromotor Sciences, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy.

Molecules (Basel, Switzerland)

|October 28, 2023

概括

这项研究表明,生物玻璃填充密封剂 (BG-PDMS) 是生物活性和重新矿化牙. 古塔珀查 (GP) 增强了这种效果,作为矿物沉积的核化场所.

科学领域:

生物材料科学生物材料科学
牙科材料科学牙科材料科学
矿化研究矿化研究

背景情况:

古塔帕查 (Guttapercha,GP) 是标准的根管填充材料,需要密封剂才能有效地堵塞.
通常使用的是基于聚甲基 (PDMS) 的密封剂.
评估新型海动物的生物活性和重矿化潜力对于内牙治疗至关重要.

研究的目的:

评估生物玻璃-PDMS密封剂 (BG-PDMS) 的生物活性和牙重矿化能力.
调查Guttapercha (GP) 对BG-PDMS海生物活性和矿化能力的影响.

主要方法:

在Hank的平衡盐溶液 (HBSS) 中,BG-PDMS密封器盘在37°C下长达28天,有或没有GP圆.
微拉曼和红外 (IR) 光谱学被用于分析材料组成和生物活性.
丹丁重矿化实验是在相同的条件下进行的.

主要成果:

BG-PDMS表现出生物活性,形成了富含的层,促进了碳酸酸盐沉积.
存在GP圆增加了由BG-PDMS形成的酸盐层的厚度.
仅GP就没有显示生物活性,但在BG-PDMS的存在下,核化酸.
BG-PDMS显著增强了牙的重矿化,这种效应被GP放大.

结论:

含有生物玻璃的PDMS密封剂 (BG-PDMS) 显示出显著的生物活性和牙重矿化潜力.
古塔珀查 (GP) 与BG-PDMS协同作用,增强了阿帕提特的形成和重矿化.
GP作为酸沉积的模板剂,改善了根运河堵塞中的整体矿化过程.

关键词:

亚酸盐是一种亚酸盐.生物玻璃是一种生物玻璃.牙重矿化牙的重矿化这就是 Guttapercha 的意思.聚二甲基西洛二氧化.转变-1,4-多聚二烯的情况振动红外和拉曼光谱学.

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