在不同 (DMSO + 水) 混合物中对伊索特列因的溶解性和热力学分析
Faiyaz Shakeel1, Nazrul Haq1, Sultan Alshehri1
1Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Molecules (Basel, Switzerland)
|October 28, 2023
概括
在二甲基硫氧化物 (DMSO) 和水混合物中的异丁 (ITN) 溶解度随着温度和DMSO度的增加而增加. DMSO显示出显著的潜力,可以提高ITN在水溶液中的可溶性.
科学领域:
- 物理化学 物理化学
- 制药科学 制药科学
- 热力学是一种热力学.
背景情况:
- 伊索特里诺因 (ITN) 是一种具有有限水溶性至关重要的制药剂.
- 了解ITN在各种溶剂系统中的溶解度对于配方开发至关重要.
- 甲基二硫氧化物 (DMSO) 是一种常见的共同溶剂,用于药物溶解.
研究的目的:
- 为了确定异二胺 (ITN) 在二甲基硫氧化物 (DMSO) +水混合物中的溶解度.
- 研究控制这些混合物中ITN溶解的热力学参数.
- 评估ITN溶解性的各种热力学模型的预测精度.
主要方法:
- 溶解度测量使用摇法在298.2318.2K的温度范围内进行.
- 在大气压下以各种DMSO+水质量分数确定ITN溶解度.
- 实验数据是使用van't Hoff,Apelblat,Buchowski-Ksiazczak λh,Yalkowsky-Roseman,Jouyban-Acree和Jouyban-Acree-van't Hoff模型进行相关联的.
主要成果:
- 在所有混合物中,ITN分子分量的溶解度随温度和DMSO质量分数的增加而增加.
- 在干净的DMSO中观察到最大的溶解率 (1.02 × 10−1在318.2 K),在纯水中观察到最小的溶解率 (3.14 × 10−7在298.2 K).
- 溶解是内热和驱动的,其中是溶解的主要驱动力;计算模型与实验数据有很好的一致性.
结论:
- 在水性混合物中,DMSO显著提高了异丁氨酸的溶解度.
- 溶解过程在热力学上是有利的,由和驱动.
- DMSO显示出作为异三胺配方的溶解剂的高潜力.
关键词:
计算模型是计算模型.这是一种异氨酸 (isotretinoin).分子相互作用分子相互作用.溶解度 溶解度 溶解度 溶解度热力学分析热力学分析{DMSO (1) +水 (2)} 混合物中的混合物.更多相关视频
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