高吸收微封装有机EPP-AF®提取物 (i-CAPs) 的开发和表征
Andresa A Berretta1, Jéssica A De Lima1,2, Soraia I Falcão3,4
1Department of Research, Development & Innovation, Apis Flora Indl. Coml. Ltd.a., Ribeirão Preto 14020-670, Brazil.
Molecules (Basel, Switzerland)
|October 28, 2023
概括
研究人员使用喷雾干燥技术开发了新的微囊 (i-CAPS). 这些增强的微囊为功能性食品和制药应用提供了更好的水溶性和生物可用性.
科学领域:
- 食品科学与技术 食品科学与技术
- 生物技术是生物技术.
- 自然产品 化学 化学
背景情况:
- 对有机和功能性食品的需求不断增加.
- 提供抗微生物,抗氧化和抗炎功效,但在乙醇溶液中生物利用性较差.
- 在开发具有更好的味道和安全性特征的水溶性,有机合格的替代品方面存在挑战.
研究的目的:
- 开发和描述水溶性微囊 (i-CAPS) 使用喷雾干燥机技术.
- 评估开发的微囊的生物活性和透性.
- 为解决传统以乙醇为基础的提取物在食品和制药用途中的局限性.
主要方法:
- 喷雾干燥技术可以从EPP-AF®和阿拉伯中制造微囊.
- 使用FT-IR,SEM,TGA,HPLC和光谱法进行表征.
- 在体外评估抗微生物,抗氧化剂,抗瘤,抗炎和抗高胆固醇活动,以及透性.
主要成果:
- 生产了具有93.7%封装效率的球形微囊.
- 已证明具有强烈的抗氧化活性 (FRAP和DPPH IC50s),对抗格拉姆阳性细菌具有优越的抗菌作用,并具有显著的抗瘤作用.
- 通过降低胆固醇透率和提高关键化合物的透性 (p-coumaric acid,artepillin C) 来表现出抗高胆固醇的活性.
结论:
- 开发的微囊 (i-CAPS) 显示出作为功能性食品和制药成分的巨大潜力.
- 微封装技术提高了的水溶性,生物可用性和生物活性.
- 建议进行进一步的研究,以证实广泛应用的拟议剂量的安全性.
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