一个地球:人类和细菌世界之间的平衡
Alicia Bravo1, Ana Moreno-Blanco1, Manuel Espinosa1
1Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas (CSIC), Ramiro de Maeztu 9, E-28040 Madrid, Spain.
International journal of molecular sciences
|October 28, 2023
概括
抗生素耐药性是一个日益增长的威胁,导致无法治疗的感染. 了解抵抗体,移动体和尼体,以及促进与细菌的共存,可以帮助对抗超级细菌并保护微生物的生物多样性.
科学领域:
- 微生物学 微生物学
- 遗传学 遗传学是一种遗传学.
- 公共卫生 公共卫生
背景情况:
- 在人类,牲畜和农业中滥用抗生素导致多药耐药细菌的出现,称为"超级细菌".
- 超级细菌感染越来越难以治疗,导致预计到2050年每年有1000万人死亡.
- 了解抗生素耐药性的遗传基础对于开发有效的干预措施至关重要.
研究的目的:
- 审查与抗生素耐药性相关的关键概念:抵抗体,移动体和尼体.
- 讨论对抗耐药病原体引起的细菌感染的策略.
- 提出一种转向与细菌世界共存的模式,以保护微生物的生物多样性.
主要方法:
- 关于科学概念和策略的文献综述.
- 对导致抗生素耐药性的遗传和移动因素的分析.
- 对人类与细菌相互作用的生态和进化观点的讨论.
主要成果:
- 抵抗体包括所有赋予抗生素耐药性的细菌基因.
- 移动基因组包括可移动的遗传元素,可通过横向基因转移促进抗性基因的传播.
- 尼科姆包括细菌在利基殖民期间表达的基因.
结论:
- 对于对抗生素耐药性的解决,全面了解抵抗体,移动体和尼体是必不可少的.
- 建议采取超越根除的战略,重点关注共存和微生物多样性,以实现可持续的方法.
- 促进微生物生物多样性对于面对气候变化的生态系统弹性至关重要.
相关概念视频
01:24Biodiversity and Human Values
13.2K
Human civilization relies on biodiversity in many ways. Sudden changes in species biodiversity result in environmental changes that can modify weather patterns and therefore human civilizations.
13.2K
01:16Non-equilibrium in the Cell
4.5K
An important concept in studying metabolism and energy is that of chemical equilibrium. Most chemical reactions are reversible. They can proceed in both directions, releasing energy into their environment in one direction, and absorbing it from the environment in the other direction. The same is true for the chemical reactions involved in cell metabolism, such as the breaking down and building up of proteins into and from individual amino acids, respectively. Reactants within a closed system...
4.5K
01:28Bacterial Growth Curve
54
The bacterial growth curve is a fundamental concept in microbiology that describes the dynamics of bacterial population growth in a closed system with controlled environmental conditions, such as temperature and nutrient availability. This curve is divided into four distinct phases: lag, log (exponential), stationary, and death phases, each reflecting a unique stage of bacterial adaptation and growth. During the lag phase, bacteria acclimate to their surroundings by synthesizing essential...
54
01:29Coordination of Gene Expression Processes in Bacteria
26
The DNA replication, transcription, and translation processes are intricately coupled in bacteria, allowing efficient gene expression and rapid protein synthesis. While this physical and functional coordination is advantageous, it introduces challenges that bacteria overcome through specific regulatory mechanisms.Coupling of Replication, Transcription, and TranslationThe coupling of replication, transcription, and translation is a hallmark of bacterial gene expression. As the replisome unwinds...
26
01:26Defense Mechanism Against Infection
6.5K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
6.5K
03:11The Equilibrium Constant
47.9K
Consider the oxidation of sulfur dioxide:
47.9K