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自闭症中的细胞因子动态:对BMAC治疗结果的分析
Dusan M Maric1,2, Danilo Vojvodic3,4, Dusica L Maric5
1Department for Research and Development, Clinic Orto MD-Parks Dr Dragi Hospital, 21000 Novi Sad, Serbia.
International journal of molecular sciences
|October 28, 2023
概括
调查自闭症谱系障碍 (ASD),这项研究分析了大脑脊髓液 (CSF) 细胞因子在骨髓吸附缩物 (BMAC) 治疗前后. 特定的细胞因子概况可以预测ASD患者的治疗反应.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
背景情况:
- 自闭症谱系障碍 (ASD) 越来越多地与中枢神经系统内的神经炎症和免疫系统失调有关.
- 在ASD中,免疫反应和神经症状之间的精确相互作用需要进一步阐明.
- 了解特定的免疫机制及其在自闭症中的神经相关性至关重要.
研究的目的:
- 研究大脑脊髓液 (CSF) 细胞因子配置和自闭症谱系障碍 (ASD) 患者的临床结果之间的关系,这些患者接受了自身骨髓吸附缩物 (BMAC) 静脉注射.
- 确定在ASD中治疗反应的潜在预测标志物.
主要方法:
- 一组80名自闭症患者 (63名男性,17名女性) 接受了三次内注射BMAC.
- 脑脊液 (CSF) 样本被分析为治疗前和后16种细胞因子的度.
- 根据第三次给药后六个月的临床改善情况,患者被分为三个组:没有/轻度,中度和重大改善.
主要成果:
- 在患者在BMAC移植前和之后之间观察到CSF细胞因子模式的显著差异.
- 不同的细胞因子概况与不同程度的ASD临床改善相关.
- 特定的细胞因子标志与BMAC治疗后缺乏显著的临床改善有关.
结论:
- 脑流细胞因子概况是预测自闭症谱系障碍患者治疗反应的有希望的途径.
- 这项研究强调了免疫标志物的潜力,以指导治疗策略和患者选择在ASD中进行BMAC干预.
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