相关实验视频
Updated: Jul 12, 2025
![An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F66708.jpg&w=3840&q=50)
10:33
An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
Published on: May 24, 2024
814
从使用液体目标的旋转机中完全自动生产[68 Ga]GaFAPI-46与-68
Alexandra I Fonseca1, Vítor H Alves1,2, Ivanna Hrynchak1
1ICNAS Pharma, University of Coimbra, 3004-531 Coimbra, Portugal.
International journal of molecular sciences
|October 28, 2023
概括
循环天文仪产生的-68可提高Ga-68 FAPI-46的产量,用于PET成像. 这种方法比发电机产生更高的活性,满足有效瘤检测的临床需求.
科学领域:
- 核医学就是核医学.
- 放射性药物化学 放射性药物化学
- 定子发射断层扫描 (PET) 成像成像
背景情况:
- 基于-68 (68Ga) 的放射性药物对PET瘤成像至关重要.
- 目前对68Ge/68Ga发电机的依赖限制了活动生产.
- 68Ga的旋转子生产提供了一个可扩展的替代方案.
研究的目的:
- 为了优化[68Ga]GaFAPI-46.的良好制造实践 (GMP) 生产.
- 为了利用通过有液体目标的医疗旋转器产生的68Ga.
- 为验证临床使用的合成和分析方法.
主要方法:
- 使用IBA Synthera®扩展模块优化了[68Ga]GaFAPI-46的GMP合成.
- 通过使用液体目标的医疗循环仪产生68Ga.
- 根据Ph. 博士的质量控制的验证分析方法. 欧元. 欧元. 在欧元. 标准. 标准. 标准. 标准.
主要成果:
- 成功生产具有高放射性化学纯度 (>98.94%) 和产量的[68Ga]GaFAPI-46.
- 在EOP时,循环生产的68Ga产生了4.31 ± 0.36 GBq.
- 经验证的GMP批量在EOS生产了2.50 ± 0.46 GBq,质量维持了3小时.
结论:
- 使用循环仪生产的68Ga可行生产[68Ga]GaFAPI-46的验证的GMP生产.
- 与发电机相比,这种方法显著增加了活性,解决了临床需求.
- 已建立的质量控制确保适合常规的临床PET成像.
更多相关视频
08:55A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
Published on: April 17, 2019
17.7K
10:20Automation of a Positron-emission Tomography PET Radiotracer Synthesis Protocol for Clinical Production
Published on: October 26, 2018
11.3K
相关概念视频
01:25Imaging Studies II: Positron Emission Tomography and Scintigraphy
130
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Fundamental Principles of PET
130
03:20Nuclear Transmutation
17.6K
Nuclear transmutation is the conversion of one nuclide into another. It can occur by the radioactive decay of a nucleus, or the reaction of a nucleus with another particle. The first manmade nucleus was produced in Ernest Rutherford’s laboratory in 1919 by a transmutation reaction, the bombardment of one type of nuclei with other nuclei or with neutrons. Rutherford bombarded nitrogen-14 atoms with high-speed α particles from a natural radioactive isotope of radium and observed...
17.6K