拉曼光谱作为甲状腺结节评估的潜在辅助:系统性审查
Monika Kujdowicz1,2, Dominika Januś3,4, Anna Taczanowska-Niemczuk5,6
1Department of Pathomorphology, Faculty of Medicine, Jagiellonian University Medical College, Grzegorzecka 16, 31-531 Krakow, Poland.
International journal of molecular sciences
|October 28, 2023
概括
拉曼光谱 (RS) 显示出诊断甲状腺结节 (TNs) 的前景. 这种技术可以准确地区分良性和恶性甲状腺瘤,从而有可能提高诊断准确性和患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 生物化学 生物化学
- 频谱学是一种光谱学.
背景情况:
- 甲状腺结节 (TNs) 是常见的,女性的发病率更高.
- 目前的差异诊断依赖于细针吸收活检,这可能是主观的.
- 准确的诊断对于适当的患者管理至关重要.
研究的目的:
- 审查关于拉曼光谱 (RS) 在甲状腺结节的差异诊断中的应用文献.
- 评估RS作为甲状腺瘤诊断工具的潜力.
主要方法:
- 在Web of Science,PubMed和Scopus上进行了系统的文献搜索,直到2023年6月.
- 确定了19项利用RS进行甲状腺结节差异诊断的研究.
- 在细胞,组织和血清样本水平上使用各种激光波长进行RS调查.
主要成果:
- 拉曼光谱在检测甲状腺癌方面表现出很高的准确性:乳头甲状腺癌约为90%,骨髓和卵泡类型高达100%.
- 生物化学分析显示,与良性结核相比,恶性结核中蛋白质,氨基酸和核酸含量增加.
- 潜在的偏见包括一些研究中的小样本大小和模型过拟合.
结论:
- 拉曼光谱是一种强大的,无标签的技术,用于甲状腺瘤诊断.
- RS提供了客观的光谱特征来区分良性和恶性甲状腺结节.
- 需要对更大的队列进行进一步的研究来验证这些发现.
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