关于shikonin-loadedβ-cyclodextrin形成宿主-客人综合体的抗氧化作用的研究,防止皮肤从光衰老
Yan Yue1, Yuqing Fang1, Ruoyang Jia1
1College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.
International journal of molecular sciences
|October 28, 2023
概括
在β-环氧德克斯 (SH-β-CD) 中封装的西康宁有效地治疗紫外线诱导的皮肤光衰. 这种新的配方增强了药物的溶解性和抗氧化活性,为皮肤护理和疾病治疗提供了有前途的治疗潜力.
科学领域:
- 皮肤病学 皮肤病学
- 药品制造 药品制造 药品制造
- 纳米技术 纳米技术
背景情况:
- 紫外线 (UV) 辐射暴露导致自由基的积累,导致皮肤脂质损伤和光衰老.
- 局部抗氧化剂组合疗法是管理皮肤光衰老的可行策略.
- 石康宁 (SH) 具有对皮肤健康有益的抗氧化特性.
研究的目的:
- 将什科宁封装在β-环氧化 (SH-β-CD) 中,以增强其溶解性并控制其释放.
- 评估SH-β-CD的抗氧化和抗脂类过氧化潜力.
- 评估SH-β-CD在UV诱导皮肤光衰老的小鼠模型中的治疗效果.
主要方法:
- 石康宁被封装在β-环氧素中,使用沉结晶.
- 对SH-β-CD的表征包括粒子大小,泽塔潜力和封装效率.
- 在体外和体外释放药物的研究使用透析膜进行.
- 在体外进行了抗氧化剂和抗脂质过氧化试验.
- 用小鼠模型来评估SH和SH-β-CD对紫外线引起的皮肤损伤的影响.
主要成果:
- SH-β-CD的平均直径为203.0 ± 21.27 nm,封装效率为65.9 ± 7.13%.
- 在体外和体外释放率分别为52.98 ± 1.21%和88.25 ± 3.26%.
- 在体外试验证实了SH-β-CD.的抗氧化和抗脂类过氧化能力.
- 在小鼠中,SH-β-CD显著改善了皮肤损伤,并增加了皮肤超氧化物脱酶 (SOD) 活性.
结论:
- SH-β-CD配方增强了什科宁的溶解性,并提供了受控的药物释放.
- 在小鼠中,SH-β-CD显示出针对紫外线诱导的皮肤光衰老的显著治疗效果.
- 这种配方有望在皮肤病学和护肤应用中开发新型治疗方法.
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