听力障碍中的代谢学分析的系统审查:它是理解听觉病理学的可能工具吗?
Rita Malesci1, Martina Lombardi2,3,4, Vera Abenante2
1Department of Neuroscience, Reproductive Sciences and Dentistry (Audiology and Vestibology Service), University of Naples Federico II, 80138 Napoli, Italy.
International journal of molecular sciences
|October 28, 2023
概括
代谢学为了解听力损失提供了一种新的方法,听力损失是一种常见的疾病,影响着数百万人. 这份综述强调了与听力损失相关的代谢变化,但呼吁在未来的研究中采用标准化的方法.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 代谢学 代谢学 代谢学
- 遗传学 是一个遗传学.
背景情况:
- 听力损失是一个普遍存在的全球健康问题,其原因复杂.
- 目前对听力损失病原体的理解仍然不完整.
- 代谢学提供了对生物过程和疾病状态的洞察.
研究的目的:
- 审查听力损失研究中代谢学方法的当前文献.
- 为了确定与各种形式的听力障碍相关的代谢变化.
- 突出挑战,并建议该领域的未来方向.
主要方法:
- 对20篇原创文章进行了全面的文献综述.
- 包括人类和动物研究.
- 与听力损失和耳毒性相关的代谢数据的分析.
主要成果:
- 特定的代谢变化与听力损失和药物诱导的耳毒性有关.
- 代谢学可以揭示听力障碍的潜在病原性机制.
- 显著的异质性,缺乏标准化和小样本大小限制了当前的发现.
结论:
- 代谢学是理解听力损失的一个有希望的工具.
- 标准化的方法和更大的研究对于可靠的结果至关重要.
- 未来的研究应该解决目前对先进诊断和治疗的局限性.
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