通过菌体疗法调节沙门氏菌感染肉中的菌微生物群和新陈代谢资料
Laura Lorenzo-Rebenaque1, Cristina Casto-Rebollo2, Gianfranco Diretto3
1Department of Animal Production and Health, Veterinary Public Health and Food Science and Technology, Biomedical Research Institute, Faculty of Veterinary Medicine, Cardenal Herrera-CEU University, CEU Universities, Calle Santiago Ramón y Cajal 20, Alfara del Patriarca, 45115 Valencia, Spain.
International journal of molecular sciences
|October 28, 2023
概括
菌体治疗通过改变肠道细菌和代谢物,有效控制 brojlers 中的沙门氏菌. 这种方法调节了白内障微生物组和代谢组,而不会对 brojler 的生长性能产生负面影响.
科学领域:
- 兽医微生物学 兽医微生物学
- 胃肠道生理学 胃肠道生理学
- 菌体研究 研究 菌体研究
背景情况:
- 菌体治疗提供了一种有针对性的方法来控制家禽生产中的沙门氏菌等动物感染细菌.
- 菌体对细菌宿主具有特异性,最大限度地减少对肠道微生物群的破坏.
- 有限的数据存在于肠道环境对禽类的菌体治疗的反应.
研究的目的:
- 为了研究沙门氏菌对 brojler 主体生理学的影响.
- 为了分析菌体的微生物群和菌体管理后的代谢组调节.
- 评估对宿主生长表现的影响.
主要方法:
- 利用16S rRNA基因测序进行微生物群分析.
- 采用非向的代谢学来分析白内障代谢物.
- 分析了用菌体治疗的沙门氏菌感染肉的阴和血清样本.
主要成果:
- 菌体治疗没有改变囊微生物群的α或β多样性.
- 在110个细菌属中,14个细菌属的相对丰富性中观察到显著的变化.
- 便代谢组分析显示了63个上升积累的代谢物和37个下降积累的代谢物的变化.
- 血清的最小变化表明没有显著的生理反应.
结论:
- 沙门氏菌素菌体的应用调节了肉的阴微生物组和代谢组配置文件.
- 菌体疗法在生产条件下没有对宿主生理或生长性能产生负面影响.
- 菌体治疗为肉生产中的沙门氏菌控制提供了一个可行的策略.
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