网络药理和生物信息学研究基尼化物调节结肠直肠癌中氧化应激的研究
Yingzi Wu1, Jinhai Luo1, Baojun Xu1
1Guangdong Provincial Key Laboratory IRADS, Department of Life Sciences, BNU-HKBU United International College, Zhuhai 519087, China.
International journal of molecular sciences
|October 28, 2023
概括
吉尼胺通过调节氧化应激来对抗结肠直肠癌 (CRC). 这项研究确定了关键的基因和涉及的途径,揭示了基因化物.
科学领域:
- 综合性瘤学和分子药理学.
- 网络药理和生物信息学在癌症研究中的应用.
背景情况:
- 结肠直肠癌 (CRC) 是一个重要的全球健康问题.
- 氧化应激对CRC的发展和进展起着至关重要的作用.
- 天然化合物基尼胺显示出潜在的治疗效果,但其在CRC中的机制尚未完全阐明.
研究的目的:
- 阐明基尼化物调节结直肠癌中氧化应激的机制.
- 为了确定关键的分子点和途径,涉及到基尼胺的抗CRC效应.
- 为基尼胺作为CRC的潜在治疗剂提供科学依据.
主要方法:
- 网络药理学和生物信息学分析以确定基因类标,CRC标和与氧化压力相关的标.
- 蛋白与蛋白相互作用 (PPI) 网络分析以确定枢纽基因.
- 基因本体学 (GO) 和基因和基因组的京都百科全书 (KEGG) 路径丰富分析.
- 分子对接,GEPIA,HPA和starBase数据库用于枢纽基因验证.
主要成果:
- 确定了五个枢纽基因 (IL1B,GSK3B,NOS3,RELA,CDK4) 对于基因的作用至关重要.
- 对GO的分析表明,它参与了诸如对温度刺激的反应和氧化代谢等过程.
- 凯格分析突出了重要的途径,包括PI3K-Akt,IL-17,p53,NF-κB和NOD类受体信号传递.
- 分子对接证实了基因和已识别的枢纽基因之间的良好结合活性.
结论:
- 热尼胺有效调节结直肠癌中的氧化应激.
- 基尼胺的抗癌作用与其对多种生物过程和信号通路的调节有关.
- 诱导氧化应激是一种潜在的机制,它是基尼胺在CRC中的抗复发和抗转移效应的潜在机制.
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