在患有家族性高胆固醇血症的患者中,血清干细胞衍生因子-1的降低及其与脂质蛋白分片的强烈相关性
Lilla Juhász1,2, Hajnalka Lőrincz1, Anita Szentpéteri1
1Division of Metabolic Diseases, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
International journal of molecular sciences
|October 28, 2023
概括
在家族性高胆固醇血清患者中,细胞衍生因子-1 (SDF-1) 的水平较低,与脂质相关. 这表明动脉样硬化发展和脂蛋白代谢的共同途径.
科学领域:
- 心血管生物学 心血管生物学
- 脂质代谢 脂质代谢是什么
- 动脉样硬化研究 动脉样硬化研究
背景情况:
- 干细胞衍生因子-1 (SDF-1) 在动脉样硬化中起着复杂的作用.
- 它与高脂血症的关系尚不清楚.
- 没有任何研究检查了在异性家族高胆固醇血清SDF-1 (HeFH) 和其脂质相关性.
研究的目的:
- 在未经治疗的HeFH患者中检查血清SDF-1水平.
- 为了确定血清SDF-1和脂质分数/分数之间的相关性.
- 探索SDF-1,氧化LDL (oxLDL) 和HeFH中的髓氧化酶 (MPO) 之间的关系.
主要方法:
- 招募了81名未经治疗的高高风患者和32名健康对照.
- 血清SDF-1,oxLDL和MPO使用ELISA进行了量化.
- 使用Lipoprint分析了脂蛋白分片,通过荷兰脂质临床网络标准诊断FH.
主要成果:
- 与对照组相比,HeFH患者的血清SDF-1显著降低.
- 血清SDF-1显示与总胆固醇,甘油三,LDL胆固醇 (LDL-C) 和阿波利波蛋白B100 (ApoB100) 的负相关性.
- 此外,SDF-1与VLDL,IDL,大LDL和大/中等HDL分数呈负相关性,但与平均LDL大小和小HDL呈正相关性;与oxLDL和MPO呈负相关性. VLDL和oxLDL是血清SDF-1的最佳预测剂.
结论:
- 在HEFH患者的低血清SDF-1表明病情中的作用.
- SDF-1和各种脂质参数之间的强烈相关性表明共享的代谢途径.
- 这些发现支持SDF-1参与动脉动脉生成,特别是在超脂血症的背景下.
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