胃癌免疫治疗的预测生物标志物:目前的状况和新兴前景
Wanting Hou1,2, Yaqin Zhao1,2, Hong Zhu1
1Division of Abdominal Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu 610065, China.
International journal of molecular sciences
|October 28, 2023
概括
确定胃癌免疫治疗的最佳生物标志物对于患者选择至关重要. 多种omics方法正在出现,以发现新的预测生物标志物,改善治疗结果.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 生物标志物发现发现
背景情况:
- 胃癌治疗面临挑战,免疫疗法提供了新的希望,但许多患者的反应率有限.
- 预测免疫疗法反应至关重要,因为不响应和潜在的不良事件.
- 现有的生物标志物,如PD-L1表达和瘤突变负担在预测胃癌免疫疗法的有效性方面存在局限性.
研究的目的:
- 审查胃癌免疫治疗的已知生物标志物.
- 引入新的生物标志物通过胃癌免疫治疗的多omics研究确定.
- 加强患者分层,优化胃癌的治疗策略.
主要方法:
- 对胃癌免疫疗法的临床确定的生物标志物的文献综述.
- 探索用于新生物标志物识别的近期多主题研究.
- 对生物标志物限制的分析以及改善患者选择的潜力.
主要成果:
- 一些生物标志物,包括PD-L1,TMB,MSI,EBV,ctDNA和TILs,显示出潜力,但存在局限性.
- 多omics技术为发现新的预测生物标志物提供了一个有希望的途径.
- 改进的生物标志物识别可以使患者更好地选择免疫治疗.
结论:
- 开发可靠的预测生物标志物对于最大限度地提高胃癌免疫疗法益处至关重要.
- 多omics集成对推动生物标志物在这个领域的发现具有重大前景.
- 通过先进生物标志物的精细患者分层将改善胃癌免疫疗法的治疗结果.
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