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微RNA作为创伤后发作的潜在生物标志物:系统性审查

Anastasia A Vasilieva¹, Elena E Timechko¹, Kristina D Lysova¹

¹Department of Medical Genetics and Clinical Neurophysiology of Postgraduate Education, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk 660022, Russia.

International journal of molecular sciences

|October 28, 2023

概括

预测发病,脑损伤后的发病的发展,是具有挑战性的. 这项研究审查了microRNAs (miRNAs) 作为潜在的生物标志物,发现miR-21,miR-181a和miR-155参与了相关的生物过程.

科学领域:

神经科学是一个神经科学.
生物标志物发现发现
分子生物学分子生物学

背景情况:

生,在脑损伤后导致的过程,有一个潜伏期,神经网络重组发生.
预测发症是临床神经学中一个关键的未满足的需求.
微RNAs (miRNAs) 正在成为病理过程的可访问生物标志物.

研究的目的:

系统地评估循环微RNAs的预测潜力,以确定发生发症的风险.
识别与前的疾病相关的特定微RNA,如创伤性脑损伤和缺血性中风.

主要方法:

在MDPI,PubMed,ScienceDirect和Web of Science进行了系统的文献搜索.
审查了分析,创伤性脑损伤和缺血性中风中的循环microRNA的出版物.
分别对31份,19份和48份手稿进行了,TBI和中风生物标志物的分析.

主要成果:

三种微RNAmiR-21,miR-181a和miR-155经常被研究.
miR-21和miR-155与细胞增殖和细胞亡有关.
miR-181a与蛋白质修饰有关,这些过程可能与发性有关.

结论:

虽然没有严格的特异性,miR-21,miR-181a和miR-155显示间接关联与发.
结合研究这些microRNA并考虑采样时间和流体类型等因素至关重要.
需要进一步深入,长期的研究,以建立基于microRNA的生物标志物来预测发生.

关键词:

生物标志物生物标志物是一种.缺血性中风中风这是一个微型RNA.创伤性脑损伤是一种创伤性脑损伤

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相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...