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微环境和循环乳酸盐在乳腺癌中的重要性

Vincenza Frisardi¹, Simone Canovi², Salvatore Vaccaro³

¹Geriatric Unit, Neuromotor Department, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy.

International journal of molecular sciences

|October 28, 2023

概括

乳腺癌细胞严重依赖葡萄糖代谢,产生乳酸. 乳酸水平升高可能表明预后较差,表明乳酸是潜在的治疗点.

科学领域:

生物化学生物化学
在瘤学瘤学.
代谢途径代谢途径

背景情况:

癌细胞表现出改变的葡萄糖代谢,有利于糖溶解.
瘤微环境,包括缺氧和树皮细胞,有助于细胞外酸化.
代谢可塑性是攻击性乳腺癌表型的标志.

研究的目的:

为了研究乳酸在乳腺癌中的作用.
探索乳酸作为乳腺癌治疗的潜在代谢标.

主要方法:

分析癌细胞中的代谢途径.
审查关于循环乳酸水平的初步科学证据.

主要成果:

乳腺癌细胞表现出向糖溶性代谢的转变,产生大量的乳酸盐.
细胞外矩阵酸化与瘤 stromal 细胞和缺氧有关.
初步数据表明,高循环乳酸盐 (超乳酸血症) 和乳腺癌预后不佳之间存在相关性.

结论:

乳酸生产及其相关的代谢转变是乳腺癌的特征.
超乳糖血症显示出作为乳腺癌预后生物标志物的潜力.
乳酸盐作为乳腺癌治疗的治疗点需要进一步研究.

关键词:

这是一种酸性症.有氧糖解有氧糖解.乳腺癌乳腺癌乳腺癌乳酸乳酸是一种乳酸.

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