中性粒细胞对牙周炎和牙周炎相关心血管疾病的贡献
Barbara Bassani1, Martina Cucchiara1,2, Andrea Butera3
1Laboratory of Innate Immunity, Unit of Molecular Pathology, Biochemistry and Immunology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) MultiMedica, 20138 Milan, Italy.
International journal of molecular sciences
|October 28, 2023
概括
中性粒细胞功能障碍导致牙周炎和相关的全身性疾病. 了解这种联系是开发口腔和整体健康新疗法的关键.
科学领域:
- 免疫学 免疫学 免疫学
- 牙周病学 牙周病学
- 口腔微生物学 口腔微生物学
背景情况:
- 中性粒细胞是对抗微生物威胁和维持组织平衡的关键免疫细胞.
- 牙周炎涉及慢性牙炎症和由于口腔微生物群失生症导致的组织破坏.
- 中性粒细胞功能障碍对牙周炎的发病及其系统性影响有显著的贡献.
研究的目的:
- 审查中性粒细胞在牙周炎中的复杂作用.
- 总结中性粒细胞功能障碍对牙周炎和相关并发症的贡献.
- 突出中性粒细胞作为口腔炎症和全身疾病之间的联系.
主要方法:
- 对中性粒细胞,牙周炎和并发病现有研究的文献综述.
- 在牙周炎中基因细胞激活和功能障碍背后的机制的分析.
- 检查证据,将牙周炎症与全身疾病联系起来.
主要成果:
- 在牙周炎中异常的中性粒细胞激活导致持续的炎症和组织损伤.
- 中性粒细胞调解了局部牙周炎症和系统性并发症之间的联系.
- 牙周炎与心血管疾病,糖尿病和类风湿性关节炎通过中性粒细胞活性有关.
结论:
- 中性粒细胞对牙周炎的发展和进展至关重要.
- 中性粒细胞功能障碍将口腔健康与心血管疾病和糖尿病等全身性疾病联系在一起.
- 向中性粒细胞活动为改善牙周炎和相关并发症的管理提供了潜力.
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