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相关概念视频

Synthesis and Regulation of Thyroid Hormones01:20

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
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Autoimmune Disorders01:29

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Development of Immunocompetence01:22

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
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The Thyroid Gland01:23

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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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在怀孕期间自身免疫性甲状腺疾病的先天免疫力.

Tatjana Bogović Crnčić1, Neva Girotto1, Maja Ilić Tomaš1

  • 1Department of Nuclear Medicine, Faculty of Medicine, University of Rijeka, Braće Branchetta 20, 51000 Rijeka, Croatia.

International journal of molecular sciences
|October 28, 2023
PubMed
概括

自身免疫性甲状腺疾病 (AITD) 由于免疫系统的适应和荷尔蒙变化,会影响怀孕. 保持甲状腺健康对于母亲和胎儿的健康至关重要.

关键词:
在 NK 细胞中,NK 细胞是 NK 细胞.在 NKT 细胞中.自免疫性甲状腺疾病树突细胞是一种树突细胞.中性粒细胞中性粒细胞.怀孕 怀孕 怀孕 怀孕 怀孕

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科学领域:

  • 内分泌学 在内分泌学.
  • 免疫学 免疫学 免疫学
  • 生殖医学 生殖医学

背景情况:

  • 自免疫性甲状腺疾病 (AITD),包括哈西莫托甲状腺炎 (HT) 和格雷夫斯病 (GD),是常见的.
  • AITD是由复杂的遗传,环境和免疫因素引起的.
  • 怀孕由于代谢和荷尔蒙变化而显著改变甲状腺功能.

研究的目的:

  • 为了检查怀孕对自身免疫性甲状腺疾病的影响.
  • 在AITD中了解怀孕期间母亲免疫系统适应的作用.
  • 强调未经治疗的甲状腺疾病对生育能力和怀孕结果的风险.

主要方法:

  • 对AITD,怀孕和免疫系统调节的现有文献的审查.
  • 对荷尔蒙影响 (雌激素,孕,hCG) 对先天性免疫细胞,特别是NK细胞的分析.
  • 检查先前存在的甲状腺疾病对生殖健康的影响.

主要成果:

  • 怀孕引起的免疫适应和荷尔蒙变化可以加剧AITD,特别是影响NK细胞.
  • 以前存在的甲状腺功能障碍带来了诸如不孕不育,胎盘断裂,流产和早产等风险.
  • 胎儿并发症包括生长迟缓和潜在的神经发育障碍.

结论:

  • 在生育年龄的妇女和怀孕期间保持甲状腺平衡至关重要.
  • 怀孕期间先天免疫的荷尔蒙调节可能会使AITD恶化.
  • 有效的AITD管理对于成功的妊娠结果至关重要.