循环赫西米德对翻译的短期抑制同时影响雌性小鼠小岛上的线粒体功能和胰岛素分泌

Mohammed Alshafei1, Torben Schulze1, Mai Morsi1,2

  • 1Institute of Pharmacology, Toxicology and Clinical Pharmacy, Technische Universität Braunschweig, D38106 Braunschweig, Germany.

概括

循环赫西米德 (CHX) 通过影响线粒体功能和蛋白质合成,损害了新鲜岛屿中葡萄糖刺激的胰岛素释放. 这种效应在培养的小岛上有所不同,这表明在β细胞中具有不同的线粒体作用.

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