药物遗传学在一线护理中的应用:一般医生对其使用的评估
Denise van der Drift1, Mirjam Simoons2, Birgit C P Koch2
1Department of Clinical Chemistry, Erasmus MC University Medical Center, 3015 GD Rotterdam, The Netherlands.
Genes
|October 28, 2023
概括
荷兰的全科医生使用药物遗传学 (PGx) 测试,主要用于抗抑郁药,因为副作用. 然而,对PGx实施的缺乏知识仍然是广泛采用的重大障碍.
科学领域:
- 临床药理学 临床药理学
- 遗传学 遗传学 是一个
- 初级医疗保健医学 一级医疗保健医学
背景情况:
- 药物遗传学 (PGx) 提供了个性化药物治疗的潜力,但其在初级保健中的应用尚未明确定义.
- 一般医生 (GPs) 越来越多地遇到PGx,需要了解其当前的使用和挑战.
研究的目的:
- 调查荷兰全科医生订购PGx测试的模式.
- 为了确定最频繁测试的基因,药物和PGx测试的原因.
- 探索全科医生的经验和在初级保健中实施PGx的感知障碍.
主要方法:
- 在2021年Erasmus MC的全科医生订购的6300个PGx测试的回顾性分析.
- 基因测试,指示药物/药物组和测试指示 (副作用,不响应) 的分析.
- 对90名全科医生进行的调查,调查了他们对PGx实施的经验和障碍.
主要成果:
- 一般医生对1206名患者进行了6300次PGx测试;CYP2C19 (17%) 和克洛皮多格雷尔 (23%) 是最常见的.
- 抗抑郁药 (51%) 和抗高血压药 (26%) 是驱动PGx请求的主要药物组,主要是副作用 (79%) 或无反应 (27%).
- 人们更喜欢面板测试;一般医生认为PGx应用中的知识缺口是实施的关键障碍.
结论:
- 在荷兰的初级保健中,PGx被积极使用,主要用于治疗抗抑郁药的副作用.
- 对更广泛的PGx实施的一个重大障碍是一般医生缺乏足够的知识和教育.
- 进一步的教育和培训对于提高PGx在初级保健机构的有效利用至关重要.
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