针对抗药性细菌的BMAP-18及其形类型的多功能特性
Ishrat Jahan1, Sukumar Dinesh Kumar2, Song Yub Shin2
1Department of Biomedical Sciences, School of Medicine, Chosun University, Gwangju 61452, Republic of Korea.
Pharmaceuticals (Basel, Switzerland)
|October 28, 2023
概括
BMAP-18及其类似物BMAP-18-FL对抗耐药细菌表现出强大的抗菌和抗菌膜活性. BMAP-18-FL还表现出更强的抗炎作用,为新药开发提供了潜力.
科学领域:
- 生物化学 生物化学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 牛骨髓状抗微生物BMAP-28 (BMAP-28) 衍生物的抗微生物特性正在被探索.
- 从BMAP-28衍生出的BMAP-18显示出强大的抗菌活性,没有细胞毒性.
- 对BMAP-18的芳香和异质类型进行了比较疗效的研究.
研究的目的:
- 为了比较芳香BMAP-18及其异质模拟物BMAP-18-FL的抗菌,抗菌膜和抗炎性质.
- 阐明这些抗微生物的作用机制.
- 评估它们在对抗耐药细菌感染方面的潜力.
主要方法:
- 对包括MRSA和MDRPA在内的格拉姆阳性和格拉姆阴性细菌进行评估的抗菌活性.
- 机制研究包括SYTOX绿色吸收,DNA结合和FACScan分析.
- 进行了生物膜抑制和根除试验.
- 通过测量LPS刺激的巨细胞中的促炎性细胞因子表达来评估抗炎活性.
主要成果:
- 无论是BMAP-18还是BMAP-18-FL,都表现出强大的抗菌活性,对抗包括MRSA和MDRPA在内的阳性和阴性细菌.
- 酸通过膜透和细胞内向作用.
- 这两种都有效地预防和根除了MRSA和MDRPA的生物膜.
- 与BMAP-18相比,BMAP-18-FL显示出更强的抗炎活性.
结论:
- BMAP-18和BMAP-18-FL具有类似的强大的抗微生物和抗菌膜活性.
- BMAP-18-FL表现出增强的抗炎性质.
- 这些具有作为抗药性细菌和相关炎症的多功能药剂的潜力.
相关概念视频
Development of Antibiotic Resistance
17
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
17
Combined Effects of Drugs: Synergism
4.0K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
4.0K
Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Bacterial Cell Wall
22
The bacterial cell wall is an essential structural component that encases the plasma membrane, preserving cellular integrity, determining shape, and protecting against osmotic stress. This rigid yet flexible structure primarily comprises peptidoglycan, a polymer that forms a mesh-like matrix conferring mechanical strength and flexibility.Peptidoglycan Composition and StructurePeptidoglycan, the core of the bacterial cell wall, comprises alternating units of N-acetylglucosamine (NAG) and...
22
Antimicrobial Effectiveness
24
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
24
Antimicrobial Proteins
1.0K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
1.0K


