多草药和全多草药配方的协同抗高血糖和抗高脂作用
Yahya Alhamhoom1, Syed Sagheer Ahmed2, Rupesh Kumar M3
1Department of Pharmaceutics, College of Pharmacy, King Khalid University, Al Faraa, Abha 62223, Saudi Arabia.
Pharmaceuticals (Basel, Switzerland)
|October 28, 2023
概括
这项研究表明,多草药配方 (PHF) 和全多草药配方 (APHF) 有效治疗糖尿病. APHF,将PHF与甲胺结合,显示出优异的抗糖尿病和抗高脂作用,降低了甲胺剂量和风险.
科学领域:
- 药理学和植物医学.
- 自然产品化学 自然产品化学
- 糖尿病学 糖尿病学
背景情况:
- 多草药配方 (PHF) 通过降低单个草药剂量来提高治疗效果和减少副作用.
- 所有多草药配方 (APHF) 将多草药提取物与所有疗法药物结合在一起,使剂量减少和减轻不良影响.
研究的目的:
- 评估PHF和APHF在体内抗糖尿病和抗高血脂作用.
- 评估APHF的安全性和有效性,作为糖尿病管理中的潜在辅助或替代甲胺的药物.
主要方法:
- PHF是从Cassia auriculata,Centella asiatica和Zingiber officinale的提取物中制备的.
- APHF是通过将PHF与甲胺结合在各种比例中来制备的,并使用差分扫描热度计 (DSC) 评估兼容性.
- 在21天的时间里,在21天的时间里,在链毒素诱导的糖尿病大鼠中评估了体内抗糖尿病活性,并监测血糖,生物化学参数和组织病理学.
主要成果:
- 无论是PHF还是APHF,都表现出显著的抗糖尿病和抗高脂性质.
- 与单独的PHF相比,APHF表现出更强大的效果.
- 组织病理学分析证实了这两种配方的治疗疗效.
结论:
- 在管理糖尿病中,PHF和APHF是安全有效的.
- APHF在降低需要的甲福胺剂量方面表现有前途,从而最大限度地降低相关风险并提高治疗结果.
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