相关实验视频

Updated: Jul 12, 2025

Formation of Dispersible Taohong Siwu Tablets

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

甲胺粘粘合剂语言下药片的制备和评估

Anwar Ma'ali¹, Hani Naseef¹, Moammal Qurt¹

¹Pharmacy Department, Faculty of Pharmacy, Nursing and Health Professions, Birzeit University, Ramallah P.O. Box 14, Palestine.

Pharmaceuticals (Basel, Switzerland)

|October 28, 2023

概括

舌下粘膜片通过延长停留时间改善了维生素B12的吸收. 欧德拉吉特L100-55片显示出增强的停留时间,粘膜粘合和透性,从而提高生物可用性.

科学领域:

制药科学制药科学
药物输送系统药物输送系统
生物化学生物化学

背景情况:

科巴胺 (维生素B12) 对于细胞功能至关重要,但其口服生物可用性较低.
提高维生素B12的吸收对于治疗疗效至关重要.

研究的目的:

开发一种语言下粘膜粘合剂片来改善维生素B12的吸收.
为了增加可胺在注射部位的停留时间,以提高生物可用性.

主要方法:

准备各种安慰剂和含有蓝甲胺的语言下药片 (S1-S20).
评估了ex vivo停留时间,粘膜粘合强度,药物含量和溶解概况.
使用弗朗茨扩散细胞进行Permeapad®透试验,以评估药物的透性.

主要成果:

使用Eudragit L100-55的S11公式,表现出最佳的粘膜粘合剂停留时间 (118.2±2.89分钟) 和脱落力 (26±1g).
观察到高药物含量 (99.124 ± 0.001699%) 和76.85%的药物释放时间超过22小时,符合Peppas-Sahlin运动模型.
欧德拉吉特L100-55配方显示了最高的透性 (流量:6.387±1.860μg/h/cm2超过6小时).

结论:

语言下粘膜片有效增加维生素B12的停留时间.
欧德拉吉特L100-55是一种有前途的聚合物,可用于开发子语言配方,以提高维生素B12的生物可用性.

关键词:

欧德拉吉特 L100-55 的使用情况在HPC和HPMC中,通过Permeapad®进行透测试.亚诺科巴胺是什么意思?粘膜粘合剂是一种粘合剂.克桑口香糖是什么意思?

更多相关视频

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Published on: September 28, 2022

相关概念视频

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...

Drug Delivery: Enteral Route

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...