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99m Tc标记的FAPI SPECT成像在异形性肺纤维化:初步结果

Yu Liu¹, Qian Zhang², Yuwei Zhang¹

¹Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing 100730, China.

Pharmaceuticals (Basel, Switzerland)

|October 28, 2023

概括

标有Technetium-99m的纤维细胞激活蛋白抑制剂 (99mTc-HFAPI) SPECT成像显示了诊断异常性肺纤维化 (IPF) 的前景. 这种新的成像技术与CT扫描和肺功能测试中的疾病严重程度相关.

科学领域:

核医学是一种核医学.
放射性药物成像技术的成像技术
间歇性肺病间歇性肺病

背景情况:

异形性肺纤维化 (IPF) 是一种具有不良预后的侵袭性间歇性肺病 (ILD).
激活的纤维细胞在IPF的发病过程中发挥着关键作用.
纤维细胞激活蛋白 (FAP) 图像追踪器为疾病可视化提供了潜力.

研究的目的:

评估一种新型的99mTc标记FAPI追踪器,99mTc-HFAPI,用于成像IPF患者的实用性.
评估99mTc-HFAPI摄入量与疾病严重程度之间的相关性.

主要方法:

11名IPF患者进行了连续全身扫描和SPECT/CT成像,使用99mTc-HFAPI.
计算了生物分布,剂量测量,标准化吸收值 (SUV) 和损伤与背景比率 (LBR).
分析了与高分辨率CT (HRCT) 阶段和肺功能测试 (PFTs) 的相关性.

主要成果:

99mTc-HFAPI在肝脏和肠道等器官中表现出生理吸收,没有显著的血液保留.
IPF肺部显示99mTc-HFAPI吸收率升高,与HRCT上的纤维化区域相关.
较高的HRCT阶段与显著增加的SUVmax和LBR相关 (p < 0.001),显示与总HRCT得分的线性相关性和与PFTs的中度相关性.

结论:

99mTc-HFAPI SPECT成像是IPF患者的一个有前途的新模式.
需要进一步的研究来探索其在监测疾病进展和治疗反应方面的临床价值.

关键词:

99mTc-HFAPIAPI的使用情况斯佩克特 (Spectre) 是一个运动场.剂量测量方法剂量测量方法异形性肺纤维化 (IPF) 是一种疾病.

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