基于重金属的纳米粒子作为高性能X射线计算机断层扫描对比剂
Mohammad Yaseen Ahmad1, Shuwen Liu1, Tirusew Tegafaw1
1Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea.
Pharmaceuticals (Basel, Switzerland)
|October 28, 2023
概括
与剂相比,重金属纳米颗粒提供了优越的X射线计算机断层扫描 (CT) 对比. 研究审查了它们作为高性能CT对比剂的潜力,重点关注毒性和成像性能.
科学领域:
- 纳米技术 纳米技术
- 医疗成像医学成像
- 材料科学 材料科学 材料科学
背景情况:
- 射线计算机断层扫描 (CT) 的对比剂增强了诊断成像.
- 目前的基药物有其局限性.
- 重金属纳米粒子 (NP) 提供更高的X射线衰减.
研究的目的:
- 审查基于重金属的NP用于CT对比度增强的体外和体内研究.
- 评估它们作为高性能CT对比剂的潜力.
主要方法:
- 对各种重金属NP (Au, Pt, Pd, Ag, Ce, Gd, Dy, Ho, Yb, Ta, W, Bi) 的研究进行了综述.
- 从幻影成像中分析X射线衰减效率.
- 评估体内成像性能和特征,如无毒性,体稳定性和颗粒大小.
主要成果:
- 重金属NP的X射线衰减系数比更高.
- 无毒性,体稳定性和小颗粒大小对于有效的CT对比剂至关重要.
- 在体外和体内研究证实了这些NP的成像潜力.
结论:
- 基于重金属的NP显示出作为先进的CT对比剂的显著前景.
- 进一步研究优化它们的特性是必要的临床转化.
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