埃尔肖尔兹 (Elsholtzia ciliata) 精油表现出平滑肌肉放松作用的作用
Irma Martišienė1, Vilma Zigmantaitė1,2, Lauryna Pudžiuvelytė3
1Laboratory of Membrane Biophysics, Institute of Cardiology, Lithuanian University of Health Sciences, Sukilėlių Ave. 15, LT50162 Kaunas, Lithuania.
Pharmaceuticals (Basel, Switzerland)
|October 28, 2023
概括
埃尔肖尔兹香精油 (EO) 和其 furan 化合物,2-乙 furan (2AF) 和5-甲基 (5MFF),使光滑肌肉放松,特别是在前列腺. 这种效应可能源于抑制α1-上腺体受体,这表明平滑肌肉疾病的治疗潜力.
科学领域:
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
- 生理学 生理学 生理学
背景情况:
- 来自Elsholtzia ciliata (EO) 的精油在之前的体内研究中显示出低血压作用.
- 滑动肌肉收缩在各种生理过程中起着至关重要的作用,包括血管和器官功能.
- 了解EO作用背后的机制可以导致新的治疗策略.
研究的目的:
- 研究Elsholtzia ciliata精油 (EO) 对前列腺和大动脉组织光滑肌肉收缩的影响.
- 为了确定EO中负责观察到的效应的特定化合物.
- 阐明EO及其成分对光滑肌肉的作用机制.
主要方法:
- 压力测量是在孤立的老鼠前列腺条和大动脉环上进行的.
- 用烯诱导的收缩来评估EO和已识别的化合物的放松作用.
- 用色谱分析来确定EO的化学成分.
- 进行了受体结合测试,以分析EO与α1-上腺素受体的相互作用.
主要成果:
- 乙醇表明前列腺和大动脉光滑肌的度依赖放松,对前列腺的影响更强 (IC50 = 0.24 μL/mL vs 0.72 μL/mL).
- 埃尔肖尔兹和德希德罗埃尔肖尔兹被确定为EO的主要成分.
- 衍生物2-乙 (2AF) 和5-甲基 (5MFF) 也对光滑肌肉表现出显著的放松作用.
- EO,2AF和5MFF降低了前列腺光滑肌对烯酸氨酸的反应能力,这表明它具有对抗作用.
- 在前列腺中的α1-上腺素受体上,EO表现出竞争性对抗性.
结论:
- 埃尔肖尔兹 (Elsholtzia ciliata) 精油具有显著的平滑肌肉放松特性,特别是在前列腺.
- 放松作用归因于其主要成分,包括elsholtzia, dehydroelsholtzia,和衍生物,如2AF和5MFF.
- 该机制涉及α1-上腺素受体的竞争性对抗性,这表明在涉及光滑肌过度活动的疾病中具有潜在的治疗应用.
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