开发一种纳米乳液,用于局部应用mupirocin
Bahjat Alhasso1, Muhammad Usman Ghori1, Simon P Rout1,2
1Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield HD1 3DH, UK.
Pharmaceutics
|October 28, 2023
概括
这项研究开发了一种新的mupirocin (MUP) 的纳米乳液配方,以改善局部输送. 该纳米乳液增强了皮肤沉积和抗菌功效,为治疗皮肤感染提供了有希望的替代方案.
科学领域:
- 制药科学 制药科学
- 皮肤病学 皮肤病学
- 材料科学 材料科学 材料科学
背景情况:
- 穆皮罗辛 (MUP) 是一种有效的局部抗生素,具有有限的皮肤透性.
- 现有的纳米乳液配方提高了MUP的透性,但却有较差的质性质.
- 限制包括粘度低,传播能力差,皮肤保留不充分.
研究的目的:
- 开发一种MUP的新型纳米乳液配方,以增强其物理化学和质性质.
- 为了评估MUP纳米膜的体外皮肤透,沉积和抗菌活性.
- 克服MUP纳米乳液的局限性,以改善局部药物输送.
主要方法:
- 穆皮罗辛纳米乳液被纳入卡博波尔凝 (0.75%) 在1:1的比例创建纳米乳液.
- 特性包括物理化学性质,质性行为和机械强度.
- 进行了体外皮肤透,沉积研究 (微型CT成像) 和抗菌检测.
主要成果:
- 纳米乳液表现出良好的稳定性和可取的质性质 (非牛顿假塑性行为).
- 试验室研究显示,皮肤透性较低,但与对照组相比,在8小时后局部MUP积累显著增加.
- 抗菌活性与对照组相比,在较低的MUP度下具有更高的疗效.
结论:
- MUP纳米乳液配方提供了改善的质特性和增强的皮肤沉积.
- 这种配方显示出局部抗菌剂的潜力,针对需要高沉积率和低透率的皮肤病变.
- 纳米乳液是优化局部mupirocin交付的有希望的策略.
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