对局部应用混合配方的风湿学和粘弹性分析
Maria Natalia Calienni1,2,3,4, Luis Manuel Martínez1,2, Maria Cecilia Izquierdo1,2
1Laboratorio de Bio-Nanotecnología, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Bernal 1876, Argentina.
Pharmaceutics
|October 28, 2023
概括
这项研究分析了含有超可变形脂质体 (UDL) 的局部配方的风湿性质. 结果显示,这些配方主要表现出弹性,类似固体的行为,这对于有效的皮肤输送至关重要.
科学领域:
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
- 生物医学工程 生物医学工程
背景情况:
- 超可塑性脂质体 (UDL) 是 lipophilic 和 hydrophilic 化合物的先进的输送系统.
- 在药物和化品局部配方中,UDLs有着重要的应用.
- 了解配方风湿学对于预测皮肤透和稳定性至关重要.
研究的目的:
- 描述含有UDL的混合局部配方的流体学和粘弹性特性.
- 评估UDL整合对配方行为的影响.
- 评估温度和老化对这些特性的影响.
主要方法:
- 使用Herschel-Bulkley模型对非牛顿行为进行流动分析.
- 线性粘弹性区域 (LVR) 的识别.
- 频率扫描测试以在不同温度和老化时间下确定G'和G"模块.
主要成果:
- 配方表现出非牛顿式,伪塑性行为,通过UDL整合显著改变.
- 在不同的条件下观察到主要弹性固体行为 (G'>G′′).
- δ值证实了主导的固体类特征超过液体行为.
结论:
- 纳入UDL会影响局部车辆的风学状况.
- 这些配方表现出强大的粘弹性特性,表明它们适合局部应用.
- 仔细选择车辆和配方组件对于优化基于UDL的输送系统至关重要.
相关概念视频
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