药物释放的数值机制建模从溶剂去除基于Zin的In Situ凝中释放药物
Setthapong Senarat1, Pornsarp Pornsawad2, Nutdanai Lertsuphotvanit3
1Programme of Pharmaceutical Engineering, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.
Pharmaceutics
|October 28, 2023
概括
数学建模和实验表明,基于在位形成的凝 (ISG) 能够有效地提供levofloxacin HCl. 更高的度控制了牙周口袋的药物释放率.
科学领域:
- 制药科学 制药科学
- 生物材料工程 生物材料工程
- 药物输送系统 药物输送系统
背景情况:
- 有效的药物输送系统对于改善治疗结果至关重要.
- 在现场形成凝 (ISG) 为控制药物释放提供了一个有希望的方法.
- 基于Zain的ISG正在探索本地化药物输送应用.
研究的目的:
- 通过数学模型和实验来研究从基于ain的ISG中释放的levofloxacin HCl.
- 用杯式方法在模型牙周口袋环境中模拟药物释放动力学.
- 了解配方参数和溶剂特性对药物释放的影响.
主要方法:
- 开发和描述不同度的基于的现场形成凝 (ISG).
- 实验性药物释放研究使用杯式方法模仿牙周口袋.
- 药物释放的数值模拟使用前向和中心差异公式.
- 紫外线成像可视化矩阵形成和溶剂扩散动态.
主要成果:
- 实验性药物释放数据与基于ISG的20%的数值模拟密切匹配,实现几乎完全释放 (100-105%).
- 25% w/w 基ISG的释放率较低 (70-90%),表明受聚合物矩阵密度影响的控制释放.
- 与二甲基硫氧化物相比,甘油形式作为溶剂的药物释放延长,这是由于更密集的矩阵和减少的扩散.
- 紫外线成像为矩阵形成动力学和溶剂扩散提供了洞察力,与释放概况相关联.
结论:
- 基于Zain的ISG显示了levofloxacin HCl的可调节的药物释放特征.
- 数学建模准确地预测了这些系统中的药物释放,有助于配方设计.
- 溶剂的选择显著影响药物释放时间和扩散动力学.
- 这项研究为开发定制的基于基因的ISG配方用于牙周药物输送提供了基础.
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