诊断和药物发现方面的进步对抗抗性和潜伏性结核病感染
Christian Shleider Carnero Canales1, Jessica Marquez Cazorla1, André Henrique Furtado Torres2
1Facultad de Ciencias Farmacéuticas Bioquímicas y Biotecnológicas, Vicerrectorado de Investigación, Universidad Católica de Santa María, Arequipa 04000, Peru.
潜在结核病感染 (LTBI) 的新诊断和治疗方法正在出现. 研究重点是分子诊断和新疗法,以对抗结核病 (TB) 并支持终结结核病战略.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 潜伏性结核病感染 (LTBI) 影响全球25%的人口,是活动性结核病 (TB) 的前体.
- 对于全球"结束结核病"战略来说,准确的LTBI诊断和治疗至关重要.
- 目前的诊断方法,结核素皮肤测试 (TST) 和干扰素玛释放试验 (IGRA),都有局限性.
研究的目的:
- 审查最近关于LTBI新型诊断方法的科学证据.
- 突出对LTBI的新兴治疗策略.
- 讨论新方法的潜力,以区分LTBI和活跃结核病.
主要方法:
- 关于LTBI诊断和治疗的最新科学文献的审查.
- 分析新兴的诊断技术,包括分子诊断,免疫学测试和下一代皮肤测试.
- 检查当前和试验中的抗LTBI药物治疗方法.
主要成果:
- 诊断测试的进步,包括世卫组织批准的IGRA和分子诊断,宿主免疫,表观遗传学和代谢学方面的研究.
- 下一代Mycobacterium结核病 (MTB) 抗原基皮肤检测 (TBST) 的开发显示出区分LTBI和活性结核病的前景.
- 探索新的治疗药物,包括抗LTBI药物,抗耐药结核病药物,以及新的临床前/临床候选药物.
结论:
- 新兴的诊断工具在识别LTBI并将其与活跃结核病区分开来时提供了更高的准确性.
- 正在开发新的治疗策略,以更有效地治疗LTBI.
- 进一步的研究和临床验证对于在全球范围内实施这些进展和有效打击结核病至关重要.
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