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磁纳米粒子在循环瘤细胞 (CTC) /非CTC分离中的作用

Chawapon Pipatwatcharadate¹, Poornima Ramesh Iyer^1,2, Dakrong Pissuwan^1,2,3

¹Nanobiotechnology and Nanobiomaterials Research (N-BMR) Laboratory, School of Materials Science and Innovation, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

|October 28, 2023

概括

磁纳米粒子 (MNPs) 是一种有前途的方法,可以从血液中分离罕见的循环瘤细胞 (CTC). 本综述探讨了MNP的使用情况.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

由循环瘤细胞 (CTC) 驱动的转移是癌症死亡的主要原因.
CTCs是转移的有价值生物标志物,但在血液样本中非常罕见.
有效检测CTC对于癌症诊断和治疗监测至关重要.

研究的目的:

审查使用磁纳米粒子 (MNP) 进行循环瘤细胞 (CTC) 分离的最新进展.
突出使用MNP进行CTC丰富和检测的新策略.
讨论MNP的合成及其与其他技术的集成,以加强CTC隔离.

主要方法:

关于细胞分离中的磁纳米粒子应用的文献综述.
分析使用MNP将CTC与非CTC分离的技术.
与其他粒子结合磁分离方法的讨论.

主要成果:

MNPs显示出从复杂的生物样本中丰富罕见CTC的巨大潜力.
各种基于MNP的策略可以有效地分离CTC和非CTC.
将MNP与其他材料集成,可以进一步提高磁细胞分离效率.

结论:

磁纳米粒子是隔离和检测循环瘤细胞的强大工具.
在MNP合成和应用方面的进展对于改进基于CTC的癌症诊断至关重要.
未来的研究应该专注于优化基于MNP的系统用于临床翻译.

关键词:

抗体是一种抗体.循环中的瘤细胞.金纳米颗粒的金子纳米颗粒磁性纳米粒子是一种磁性纳米粒子.分离式隔离器的使用方法

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