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稳定石墨烯氧化物分散在类似于等离子体的同位素溶液中,该溶液含有聚合度的双等价子

Marcin Z Krasoń^1,2,3, Anna Paradowska¹, Martyna Fronczek^1,4

¹Silesian Park of Medical Technology Kardio-Med Silesia, 41-800 Zabrze, Poland.

|October 28, 2023

概括

牛血清白蛋白 (BSA) 在生理溶液中有效地稳定氧化石墨烯 (GO) 纳米粒子,防止由双价引起的聚合. 这提高了GO在潜在的血管内应用中的分散性.

科学领域:

纳米材料科学科学纳米材料科学
生物材料工程生物材料工程
生物化学生物化学

背景情况:

石墨烯氧化物 (GO) 在血管内应用方面表现有前途,包括药物输送和抗菌用途,但其生物相容性和分散稳定性需要进一步研究.
诸如双价离子,粒子结构,氧含量和pH等因素显著影响GO的特性和生物相互作用.
牛血清白蛋白 (BSA) 是一种关键的血蛋白,其潜力是提高GO在生理条件下的分散稳定性.

研究的目的:

为了评估牛血清白蛋白 (BSA) 在稳定石墨烯氧化物 (GO) 分散在生理双价的存在中的有效性.
为了评估BSA对GO颗粒大小,分散性和稳定性的影响,用于潜在的血管内应用.

主要方法:

研究了四种类型的商用石墨烯氧化物 (GO) 水性分散剂.
分散被用BSA和和酸的生理度处理.
特性包括纳米颗粒大小分析 (Zetasizer NanoZS),结构分析 (TEM, CryoTEM),功能组含量 (微量定位) 和pH测量.

主要成果:

在有双价生理酸盐沉度的情况下,BSA有效地阻止了GO的聚合.
多分散度指数显著下降,从0.66-0.91降至0.36-0.43,表明粒子大小均性得到改善.
稳定,含有GO的同位素分散得到了Z-平均尺寸从382.6nm到490.1nm,这取决于GO结构.

结论:

牛血清白蛋白 (BSA) 在稳定各种石墨烯氧化物 (GO) 分散方面表现出显著的有效性.
在含有聚合双价生理的同位素溶液中,BSA确保了GO的稳定性,这对于安全的血管内应用至关重要.
在生理条件下,GO的结构影响其行为和BSA的稳定.

关键词:

水性分散的水性分散.牛血清中的牛血清专蛋白.石墨烯氧化物石墨烯氧化物离子诱导的聚合.纳米颗粒大小的纳米粒子大小.分散的稳定性分散的稳定性.

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