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黄素作为一个稳定性巨细胞极化在等离子体感染期间

Maria Clara C Cordeiro¹, Fernanda D Tomé¹, Felipe S Arruda¹

¹Department of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia 74605-050, GO, Brazil.

|October 28, 2023

概括

黄素 (CUR) 可能通过改变巨细胞功能来影响疟疾寄生虫清除. 这项研究表明,CUR平衡免疫反应,可能改善疟疾治疗结果.

科学领域:

免疫学免疫学免疫学
寄生虫学的寄生虫学
药理学药理学是指药理学的学科.

背景情况:

疟疾导致全球显著的发病率和死亡率.
感染红细胞的巨细胞化会产生活性氧和物种,帮助对寄生虫进行清除.
黄素 (CUR) 已显示出抗炎作用,并减少了小鼠的寄生病.

研究的目的:

为了研究黄素对巨细胞功能的干扰和在Plasmodium berghei感染期间的两极分化在体外.
评估黄素对巨细胞化和杀菌活性的影响.

主要方法:

在体外培养巨细胞表型 (M0,M1,M2).
用感染的红血细胞 (iRBC) 和未感染的红血细胞 (RBC) 进行化,有或没有黄素.
测量细胞酶,可诱导的氧化合成酶 (iNOS) 和酶活性.

主要成果:

与红细胞相比,所有巨细胞的表型都显示IRBC的化细胞增加.
对M1巨细胞的黄素暴露减少了它们在24小时后消除iRBC的能力.
黄素在M0巨细胞中增强了细胞形成,并在所有表型中降低了iNOS和阿基因酶活性,这表明阿基因因途径干扰和极化平衡.

结论:

黄素在疟疾感染期间调节巨细胞功能和两极分化.
它可能会干扰杀菌活性,但促进免疫反应的平衡.
黄素可以作为疟疾的辅助疗法,通过平衡亲和抗炎作用来改善临床结果.

关键词:

在 RAW 264.7 中,单元格为 264.7.这是阿尔金纳.库尔库明是一种黄素.我们的 iNOS iNOS 疟疾疟疾是一种疾病.发酵细胞的形成发酵细胞的形成

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