对氧化纳米颗粒的生物行为和抗菌性能的研究
Iason Chatzimentor1, Ioannis Tsamesidis1, Maria-Eleni Ioannou1
1Department of Prosthodontics, Faculty of Health Sciences, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Pharmaceutics
|October 28, 2023
概括
氧化 (CeO2) 纳米颗粒促进人体细胞生长和骨形成,同时抑制细菌生长,在感染和炎症控制中显示出临床应用的希望.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 细胞生物学 细胞生物学
背景情况:
- (Ce) 和其氧化物纳米粒子 (CeO2NP) 正在获得工业和生物医学应用的关注.
- 在生物医学应用中,CeO2NP显示出控制感染和炎症的潜力.
研究的目的:
- 为了研究CeO2NP的生物特性.
- 为了评估CeO2NP的抗菌行为.
主要方法:
- 使用MTT测定,评估CeO2NP与人类牙周带细胞 (hPDLC) 的生物相容性.
- 测量了性酸酶 (ALP) 和阿利沙林红色染色 (ARS) 的骨质分化.
- 在氧化应激 (H2O2) 和ROS清除特性下评估细胞活力.
- 通过对 Porphyromonas gingivalis 和 Prevotella intermedia 的抗菌能力通过宏稀释来确定.
主要成果:
- CeO2 NPs以时间依赖的方式增强了hPDLC的扩散.
- CeO2 NPs促进了hPDLCs的骨质生成分化.
- CeO2 NPs表现出ROS清除特性,并在氧化应激下保护细胞.
- 观察到抗菌活性,特别是针对P. gingivalis.
结论:
- CeO2 NPs表现出生物相容性,并促进骨质生分化.
- CeO2 NPs具有抗氧化剂和ROS清理能力.
- 在临床环境中,CeO2 NP显示出禁止细菌增殖和管理炎症状况的潜力.
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