纳米乳液作为Etodolac局部输送的有希望的载体:配方开发和表征
Samet Özdemir1, Burcu Üner2, Alptuğ Karaküçük3
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul Health and Technology University, 34445 Istanbul, Turkey.
Pharmaceutics
|October 28, 2023
概括
这项研究开发了etodolac的局部纳米乳液,改善了其传递. 这些纳米乳液表现出增强的抗炎作用和持续的药物释放,可有效地局部应用.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 药物输送系统 药物输送系统
背景情况:
- 埃托多拉克在局部输送方面存在局限性.
- 纳米乳液为改善药物配方提供了潜力.
- 开发有效的局部配方对于非类固醇抗炎药物至关重要.
研究的目的:
- 开发和优化用于etodolac.c.的局部纳米乳液.
- 为了评估etodolac纳米乳液的物理化学性质,体外释放,体外透性和抗炎活性.
- 评估纳米乳液作为局部ethodolac交付的载体.
主要方法:
- 使用高剪率均质化和超声波制备的纳米乳液.
- 通过设计实验来优化配方.
- 描述包括滴滴大小,PDI,泽塔潜力,电子显微镜,FTIR,体外释放,体外透性和体内抗炎研究.
主要成果:
- 优化纳米乳液的液滴大小为163.5nm,PDI为0.141和zeta潜力为-33.1mV.
- 在体外释放显示持续的,非Fickian药物运输.
- 外体生体研究表明,与粗分散相比,流量显著增加 (165.7比59.7μg/cm2h).
- 纳米乳液在老鼠爪胀模型中表现出增强的抗炎活性.
结论:
- 局部的etodolac纳米乳液已经成功开发出来.
- 纳米乳液显著改善了etodolac的局部输送和抗炎疗效.
- 纳米乳液代表了用于局部ethodolac配方的有希望的载体系统.
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