休息和姿势震幅度的加速计分类
Christina van der Linden1, Thea Berger1, Gregor A Brandt1
1Department of Neurology, University Hospital Cologne and Faculty of Medicine, University of Cologne, 50937 Cologne, Germany.
Sensors (Basel, Switzerland)
|October 28, 2023
概括
加速度计准确地测量了基本震 (ET) 和帕金森病 (PD) 患者的震严重程度,其表现优于传统的临床尺度. 这种客观方法有助于评估诸如深度大脑刺激 (DBS) 等治疗方法.
科学领域:
- 神经学 神经学
- 生物医学工程 生物医学工程
- 可穿戴技术可穿戴技术
背景情况:
- 临床震评估存在低分辨率和评价者偏差,限制其在门诊环境和治疗评估中的使用.
- 需要客观,定量方法来评估的严重程度和治疗效果,特别是深度脑刺激 (DBS).
研究的目的:
- 研究加速度指标以客观地分类震幅度在基本震 (ET) 和帕金森病 (PD).
- 为了比较加速度计衍生的指标与严重程度的临床评级.
主要方法:
- 在16名ET和25名PD患者的休息和姿势震任务期间,从手指和手腕佩戴的传感器收集了三轴加速度计数据.
- 利用光谱组件和纯加速指标,应用非线性回归来将传感器数据与临床评级联系起来.
- 在一个持久数据集上验证了模型,以评估预测性能和互评级可靠性.
主要成果:
- 所有测试的加速度计指标在预测临床震评级方面都显示出很高的一致性 (>70%).
- 在基于加速度计的预测中,获得了实质性的interrater可靠性 (科恩加权卡帕>0.7).
- 与手腕佩戴设备相比,手指佩戴加速度计显示出略高的性能.
结论:
- 三轴加速度计提供了一种可靠和客观的方法来量化在ET和PD患者的休息和姿势震幅度.
- 这项技术为主观临床尺度提供了可行的替代方案,特别是用于评估像DBS这样的干预措施.
- 数据集和软件的发布有助于进一步研究和开发震评估.
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