尾切除减轻了Coxsackie病毒B3诱导的病毒性心肌炎
Chengrui Niu1, Wei Xu1, Sidong Xiong1
1Jiangsu Provincial Key Laboratory of Infection and Immunity, Institute of Biology and Medical Sciences, Soochow University, Suzhou 215123, China.
Viruses
|October 28, 2023
概括
尾是肠道微生物的储存库,在调节免疫反应方面发挥着作用. 通过改变免疫细胞活性,尾切除在小鼠中减少了炎和改善了在Coxsackievirus B3 (CVB3) 感染期间的心脏功能.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 胃肠病学 胃肠病学
背景情况:
- 尾是淋巴细胞和微生物群的所在地,影响肠道菌群和IgA诱导.
- 尾切除术与心血管疾病风险增加有关.
- 尾在病毒性心肌炎中的作用尚不清楚.
研究的目的:
- 在小鼠模型中研究尾切除术对Coxsackievirus B3 (CVB3) 诱导的病毒性心肌炎的影响.
- 阐明尾细胞影响病毒性心肌炎的潜在免疫机制.
主要方法:
- 在用CVB3.3进行腹腔内接种之前,小鼠接受了尾切除或假装手术.
- 用RT-PCR量化了心脏和肠道中的病毒载量和促炎性细胞因子水平.
- 分析了免疫细胞透 (中性粒细胞,巨细胞) 和T细胞反应 (IFN-γ,IL-10).
主要成果:
- 与对照组相比,尾切除的小鼠显示心脏炎症减少,心脏功能改善,系统性病毒载量降低.
- 在被尾切除的小鼠中观察到心脏中性粒细胞和巨细胞透率的降低以及促炎性细胞因子的产生.
- 尾切除术导致肠道IL-10和调节性T细胞 (Treg) 频率降低,增强抗病毒T细胞反应 (IFN-γ) 和病毒限制.
结论:
- 尾调节对CVB3感染的免疫反应,影响心脏炎症和病毒性心肌炎.
- 尾切除术改变了肠道的免疫环境,特别是减少产生IL-10的Tregs,从而增强抗病毒免疫力.
- 这些发现表明尾在通过其对肠道免疫系统的影响来调节系统性病毒感染方面发挥着关键作用.
相关概念视频
Myocarditis III: Medical Management
7
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
7
Endocarditis III: Medical Management
8
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
8
Pericarditis III: Medical Management
13
The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
13
Appendicitis-II: Diagnostic Studies and Management
80
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
80
Appendicitis-I: Introduction
193
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
193
Myocarditis IV: Nursing Management
13
Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
13


